Source of increased plasminogen activators during pregnancy and puerperium

Thrombosis Research
H ShimadaY Takada

Abstract

We investigated the increase of plasminogen activators (tPA and uPA) in the plasma during pregnancy. Both tPA and uPA antigens were found to increase after the third trimester of pregnancy and high levels of PAs persisted through the first stage of labor. The tPA antigen levels rose further for the first few hours post-partum, while the level of uPA antigen returned to normal immediately following childbirth. To clarify whether the uterus and/or placenta are involved in the increased levels of plasma PAs, the levels were measured in uterine venous blood in cases of caesarean sections. During the ante-partum period, the level of uPA antigen in the uterine venous blood was higher than that in the peripheral venous blood, while there was no significant difference between the levels of tPA antigen in peripheral blood and uterine venous blood. The level of tPA antigen in the uterine venous blood rose after delivery. In contrast, the level of uPA antigen declined immediately after delivery. These results suggest that (1) the placenta is the major source of the increased uPA antigen during pregnancy, (2) entire vascular system is involved in the increased tPA antigen during pregnancy, (3) a further increase in tPA after delivery is du...Continue Reading

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Citations

Jun 30, 1994·European Journal of Obstetrics, Gynecology, and Reproductive Biology·H A BremerH C Wallenburg
Jun 6, 2003·Best Practice & Research. Clinical Obstetrics & Gynaecology·Máiread N O'Riordan, John R Higgins
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Nov 1, 2016·Expert Review of Hematology·Loïc SentilhesCatherine Deneux-Tharaux
May 5, 2017·PloS One·Adrienne CsutakDavid M Silver
Oct 1, 1994·Thrombosis Research·A TakadaT Urano

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