PMID: 11335000May 4, 2001Paper

Sources and sink of retinoic acid in the embryonic chick retina: distribution of aldehyde dehydrogenase activities, CRABP-I, and sites of retinoic acid inactivation

Brain Research. Developmental Brain Research
Jörg MeyM Klemeit

Abstract

Previous experiments in mice and zebrafish led to the hypothesis that an asymmetric distribution of the transcriptional activator retinoic acid (RA) causes ventral-dorsal polarity in the vertebrate eye anlage. A high concentration of RA in the ventral retinal neuroepithelium has been suggested to induce developmental events that finally establish topographic order in the retinotectal projection along the vertical eye axis. In the present study we have investigated potential sources and sinks of RA during embryonic development of the chick retina. At embryonic day (E)1 to E2, when the spatial determination of the eye primordia takes place, no RA synthesis by aldehyde dehydrogenases was detectable, and neither immunoreactivity for retinaldehyde dehydrogenase RALDH-2 nor for cellular retinoic acid binding protein CRABP-I was observed. These components of RA signal transduction appeared in the eye between E3 and E5. At later stages, RA-measurements with a reporter cell line showed highest synthesis in the retinal pigment epithelium (RPE) and at the ventral and dorsal poles of the retina. RA degradation occurred mostly in a horizontal region in the middle of the retina with only small differences along the nasal-temporal axis. CRABP...Continue Reading

References

Dec 1, 1990·Cell Differentiation and Development : the Official Journal of the International Society of Developmental Biologists·R K SinghB P Sani
Jul 1, 1990·Brain Research. Developmental Brain Research·M MomoiT Momoi
Oct 16, 1989·Biochemical and Biophysical Research Communications·T KitamotoT Momoi
Jul 19, 1994·Proceedings of the National Academy of Sciences of the United States of America·P McCaffery, U C Dräger
Jul 19, 1994·Proceedings of the National Academy of Sciences of the United States of America·N Marsh-ArmstrongU C Dräger
Aug 1, 1993·Developmental Biology·P McCaffreryU C Dräger
Jul 1, 1996·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·J L Napoli
Mar 1, 1996·Developmental Dynamics : an Official Publication of the American Association of Anatomists·R GodboutL Dabbagh
Oct 29, 1996·Proceedings of the National Academy of Sciences of the United States of America·P McCafferyU C Dräger
Nov 12, 1996·Proceedings of the National Academy of Sciences of the United States of America·G A HyattJ E Dowling
Nov 22, 1996·The Journal of Biological Chemistry·J A WhiteM Petkovich
Aug 1, 1997·Brain Research. Brain Research Protocols·P McCaffery, U C Dräger
May 29, 1998·Brain Research. Developmental Brain Research·M YamamotoP McCaffery
Dec 30, 1999·Science·K Koshiba-TakeuchiT Ogura
Apr 13, 2000·Brain Research. Brain Research Reviews·J Mey, S Thanos
Sep 28, 2005·Tropical Medicine & International Health : TM & IH·Damien de WalqueJimmy A Whitworth
Jan 1, 1951·Journal of Morphology·V HAMBURGER, H L HAMILTON

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Citations

Feb 28, 2002·Current Opinion in Neurobiology·Maureen A Peters
May 25, 2005·The Journal of Biological Chemistry·Alexander R MoiseKrzysztof Palczewski
Sep 1, 2011·BMC Developmental Biology·Craig B StevensDeborah L Stenkamp
Apr 1, 2014·Neuroscience Letters·Junfeng Mao, Shuangzhen Liu
Nov 26, 2011·Experimental Eye Research·Yuko KawazoeManabu Mochizuki
Apr 15, 2008·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Sarah GolzJörg Mey
Oct 27, 2010·Expert Review of Proteomics·Verena ProkoschSolon Thanos
May 12, 2006·Journal of Neurobiology·Raymond RomandEri Hashino
Oct 4, 2005·Developmental Biology·Shubhangi N PrabhudesaiDeborah L Stenkamp
Aug 17, 2010·Developmental Biology·H ThompsonI M McGonnell
Mar 6, 2007·Developmental Biology·Ruben Adler, M Valeria Canto-Soler
Nov 10, 2010·PloS One·Nathan A BillingsConstance L Cepko
Jul 28, 2004·The American Journal of Pathology·Kathleen HibbsAmy P N Skubitz

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