PMID: 2505654Jan 1, 1989Paper

Sources for brain arachidonic acid uptake and turnover in glycerophospholipids

Annals of the New York Academy of Sciences
L A Horrocks

Abstract

Brain arachidonic acid comes from linoleic acid and arachidonic acid in the blood. Part of the brain arachidonic acid is elongated to adrenic acid, 22:4 (n = 6), especially in higher animals. With labeled arachidonic acid injected into cerebral ventricles of mice, the highest specific radioactivity was in triacylglycerols. The highest labeling in PtdCho and PtdIns was found at 15 to 60 minutes. Labeling of PtdEtn was much less. The molecular species with 16:0 and 18:1 were labeled better than those with 18:0. Adrenic acid was preferred by alkylacyl-GroPEtn. The highest level of labeling by arachidonic acid was found in the choline plasmalogens and the alkylacyl-GroPCho at 24 hours after injection. The PtdCho arachidonic acid turned over several times within 24 hours. Part of this turnover probably represents the transfer of labeled arachidonic acid to unlabeled ether-linked choline glycerophospholipids, including 1-alkyl-2-lyso-GroPCho, also known as lyso platelet activating factor. The energy-independent transfer of arachidonic acid from PtdCho to ether-linked choline glycerophospholipids may follow removal of their arachidonic acid by phospholipase A2 due to receptor activation. The lack of pulse labeling of ether-linked chol...Continue Reading

References

Feb 1, 1988·Journal of Neurochemistry·R Spector
Jun 14, 1985·Biochemical and Biophysical Research Communications·P V Reddy, H H Schmid
Jan 1, 1973·Advances in Lipid Research·G A Dhopeshwarkar, J F Mead
Oct 1, 1971·Journal of Neurochemistry·G V MarinettiJ Kelly
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Feb 1, 1980·Journal of Neurochemistry·W M Pardridge, L J Mietus

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Citations

Sep 1, 1995·Brain Research. Brain Research Reviews·A A FarooquiL A Horrocks
Aug 1, 1995·Progress in Neurobiology·H Katsuki, S Okuda
Feb 26, 2008·European Journal of Pharmacology·Renato Malcher-LopesJeffrey G Tasker
Aug 14, 2001·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·A A Farooqui, L A Horrocks
Sep 16, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Mary XylakiEvangelia Emmanouilidou

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