Sources of clinically significant neonatal intensive care unit phthalate exposure

Journal of Exposure Science & Environmental Epidemiology
Annemarie StroustrupChris Gennings

Abstract

In the United States each year, more than 300,000 infants are admitted to neonatal intensive care units (NICU) where they are exposed to a chemical-intensive hospital environment during a developmentally vulnerable period. Although multiple studies have demonstrated elevated phthalate biomarkers in NICU patients, specific sources of NICU-based phthalate exposure have not been identified.In this study, premature newborns with birth weight <1500 g were recruited to participate in a prospective environmental health cohort during the NICU hospitalization. Exposure to specific NICU equipment was recorded daily during the NICU hospitalization. One hundred forty-nine urine specimens from 71 infants were analyzed for phthalate metabolites using high-performance liquid chromatography/tandem mass spectrometry.In initial analyses, exposure to medical equipment was directly related to phthalate levels, with DEHP biomarkers 95-132% higher for infants exposed to specific medical equipment types compared to those without that equipment exposure (p < 0.001-0.023). This association was mirrored for clinically relevant phthalate mixtures whether composed of DEHP metabolites or not (p = 0.002-0.007). In models accounting for concurrent equipment ...Continue Reading

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Citations

Apr 28, 2019·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Randall JenkinsDavid Rozansky
Sep 12, 2020·Pediatric Research·Annemarie Stroustrup
Aug 8, 2019·Journal of Perinatology : Official Journal of the California Perinatal Association·K FarnbachR Jenkins
Dec 18, 2019·Pediatric Research·Shaliz PourkavianiAnnemarie Stroustrup
May 1, 2021·Toxics·Randall JenkinsDavid Rozansky
Aug 22, 2021·Environmental Research·Christopher J MartyniukLorraine Chalifour

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Methods Mentioned

BETA
urine specimens
urine specimen collection
urine collection
PMA

Clinical Trials Mentioned

NCT01420029
NCT01963065
NCT03061890

Software Mentioned

SAS

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