SOX-10 and S100 Negative Desmoplastic Melanoma: Apropos a Diagnostically Challenging Case.

The American Journal of Dermatopathology
Sarah Kooper-JohnsonDaniel S Loo

Abstract

An 83-year-old man presented with a tumor of the neck, clinically consistent with an epidermal inclusion cyst. Excisional biopsy revealed a deeply infiltrating spindled cell tumor. Immunohistochemical markers for S100, SOX-10, Melan-A, HMB-45, and NK1/C3 were negative. Based on the presence of an area of lentigo maligna and the histologic pattern of the spindle cell component, a diagnosis of desmoplastic melanoma was made despite the absence of immunophenotypic evidence for melanocytic differentiation. To the best of our knowledge, the complete lack of both S100 and SOX-10 makes this tumor an unprecedented case. To avoid ruling out the diagnosis of desmoplastic melanoma prematurely, physicians should be made aware of this possible immunohistochemical profile.

References

Dec 1, 1996·The American Journal of Surgical Pathology·T A LongacreR V Rouse
May 23, 2008·The American Journal of Dermatopathology·Luis Soares de AlmeidaManuel Marques Gomes
Dec 14, 2011·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Daniel D MillerMeera Mahalingam
Apr 13, 2012·Applied Immunohistochemistry & Molecular Morphology : AIMM·Jason R KaramchandaniRobert B West
Jan 8, 2013·The American Journal of Dermatopathology·Beth PallaSarah Dry

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Citations

Mar 7, 2021·Journal of Cutaneous Pathology·Jina ChungJason B Lee

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