SOX10, in combination with Sp1, regulates the endothelin receptor type B gene in human melanocyte lineage cells

The FEBS Journal
Satoru YokoyamaShigeki Shibahara

Abstract

Waardenburg syndrome (WS) is an auditory-pigmentary disorder that exhibits varying combinations of sensorineural hearing loss and abnormal pigmentation of the hair and skin. WS type 4 (WS4), a subtype of WS, is characterized by the presence of the aganglionic megacolon and is associated with mutations in the gene encoding either endothelin 3, endothelin receptor type B (EDNRB), or Sry-box 10 (SOX10). Here, we provide evidence that SOX10 regulates the expression of EDNRB gene in human melanocyte-lineage cells, as judged by RNA interference and chromatin immunoprecipitation analyses. Human melanocytes preferentially express the EDNRB transcripts derived from the conventional EDNRB promoter. SOX10 transactivates the EDNRB promoter through the cis-acting elements, the two CA-rich sequences and the GC box. Moreover, a transcription factor Sp1 enhances the degree of the SOX10-mediated transactivation of the EDNRB promoter through these cis-acting elements. Furthermore, we have shown that the EDNRB promoter is heavily methylated in HeLa human cervical cancer cells, lacking EDNRB expression, but not in melanocytes and HMV-II melanoma cells. The expression of EDNRB became detectable in HeLa cells after treatment with a demethylating rea...Continue Reading

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Citations

Feb 5, 2010·Pigment Cell & Melanoma Research·Amy Saldana-Caboverde, Lidia Kos
May 7, 2010·Pigment Cell & Melanoma Research·Melissa L HarrisWilliam J Pavan
Apr 5, 2013·PloS One·Mugdha DeoCatherine D Van Raamsdonk
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Jul 1, 2015·Proceedings of the National Academy of Sciences of the United States of America·Matthew D LeComteJeffrey L Spees
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Mar 7, 2019·Pigment Cell & Melanoma Research·Eric T DomyanJonathon T Hill

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