SOX11 expression correlates to promoter methylation and regulates tumor growth in hematopoietic malignancies.

Molecular Cancer
Elin GustavssonSara Ek

Abstract

The transcription factor SOX11 plays an important role in embryonic development of the central nervous system (CNS) and is expressed in the adult immature neuron but is normally not expressed in any other adult tissue. It has recently been reported to be implicated in various malignant neoplasms, including several lymphoproliferative diseases, by its specific expression and in some cases correlation to prognosis. SOX11 has been shown to prevent gliomagenesis in vivo but the causes and consequences of aberrant expression of SOX11 outside the CNS remain unexplained. We now show the first function of SOX11 in lymphoproliferative diseases, by demonstrating in vitro its direct involvement in growth regulation, as assessed by siRNA-mediated silencing and ectopic overexpression in hematopoietic malignancies. Gene Chip analysis identified cell cycle regulatory pathways, including Rb-E2F, to be associated with SOX11-induced growth reduction. Furthermore, promoter analysis revealed that SOX11 is silenced through DNA methylation in B cell lymphomas, suggesting that its regulation is epigenetically controlled. The data show that SOX11 is not a bystander but an active and central regulator of cellular growth, as both siRNA-mediated knock-do...Continue Reading

References

Mar 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·M FrommerC L Paul
Jul 20, 1987·Journal of Molecular Biology·M Gardiner-Garden, M Frommer
Dec 6, 1996·Science·C J Sherr
Jan 1, 1996·Critical Reviews in Oncogenesis·M CallananR Rimokh
Jun 20, 1998·The Journal of Biological Chemistry·K KuhlbrodtM Wegner
Feb 13, 1999·Nature Genetics·P A Jones, P W Laird
Feb 26, 1999·Nucleic Acids Research·M Wegner
Nov 26, 1999·DNA Research : an International Journal for Rapid Publication of Reports on Genes and Genomes·T AzumaM Muramatsu
Oct 31, 2001·Trends in Cell Biology·R J Akhurst, R Derynck
Jul 9, 2002·Current Opinion in Genetics & Development·Megan Wilson, Peter Koopman
Jul 20, 2002·Journal of Neuro-oncology·Ching-Jung LeePaul J Scotting
Oct 24, 2002·Blood·Margarita Sánchez-BeatoMiguel A Piris
Nov 9, 2002·Bioinformatics·Long-Cheng Li, Rajvir Dahiya
Feb 8, 2003·Current Opinion in Genetics & Development·Scott W Lowe, Charles J Sherr
Oct 15, 2003·Nature Reviews. Cancer·Peter M Siegel, Joan Massagué
Apr 9, 2004·BMC Cancer·Jamboor K VishwanathaVelliyur K Gopalakrishnan
Aug 18, 2004·Biochemical and Biophysical Research Communications·Bernd WeigleE Peter Rieber
Nov 16, 2005·International Journal of Cancer. Journal International Du Cancer·Sara EkCarl A K Borrebaeck
Aug 15, 2006·Biochimica Et Biophysica Acta·Katerina Pardali, Aristidis Moustakas
Aug 29, 2006·Oncogene·L LeonciniG De Falco
Oct 10, 2006·Molecular Cancer·John Hayslip, Alberto Montero
Dec 22, 2006·Genes & Development·Maria BergslandJonas Muhr
May 15, 2007·The International Journal of Biochemistry & Cell Biology·Joern LewinReinhold Wasserkort
Dec 7, 2007·Cancer Letters·Ulrika AndréassonCarl A K Borrebaeck
Feb 12, 2008·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Kirsten GrønbaekPer Guldberg
Mar 21, 2008·Proceedings of the National Academy of Sciences of the United States of America·Mathias EhrichDirk van den Boom
Mar 11, 2009·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Donal J BrennanCarl A K Borrebaeck
Jun 6, 2009·The European Journal of Neuroscience·Anja HaslingerD Chichung Lie
Sep 5, 2009·Nature Reviews. Cancer·David W Meek
Oct 6, 2009·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Yi-Hua ChenLoAnn C Peterson
Dec 18, 2009·Cell Cycle·Carmen Dominguez-BrauerPradip Raychaudhuri
Feb 4, 2010·Cancer Research·Verònica FernàndezElías Campo

❮ Previous
Next ❯

Citations

May 19, 2011·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Woonbok ChungJean-Pierre J Issa
Jul 9, 2011·PloS One·Maria Carmela VeglianteVirginia Amador
May 10, 2013·PloS One·Bi-Qing LiYu-Dong Cai
Aug 4, 2011·Haematologica·Michelle Furtado, Simon Rule
Jan 14, 2016·Leukemia & Lymphoma·Venera KuciSara Ek
Mar 17, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Zhiyong YaoHeqing Guo
Sep 5, 2013·Leukemia Research·Ting-Xun LuWei Xu
Jan 23, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Alejandro RoismanIrma Slavutsky
Mar 25, 2015·Cellular Oncology (Dordrecht)·Xiaoyang XuDongqiu Dai
Nov 22, 2016·Leukemia & Lymphoma·Tove WästerlidSara Ek
Jul 23, 2013·The Journal of International Medical Research·Jiao JianZhao Jing
Sep 18, 2014·Applied Immunohistochemistry & Molecular Morphology : AIMM·Megan O NakashimaEric D Hsi
Oct 17, 2017·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Ping He, Xiaojie Jin
May 9, 2018·Current Opinion in Hematology·Renée BeekmanElias Campo
Jan 19, 2012·The American Journal of Surgical Pathology·Weifen ZengEric D Hsi
Jan 10, 2018·International Journal of Experimental Pathology·Apiwat PugongchaiPichet Sampatanukul
May 4, 2017·Current Oncology Reports·Sílvia Beà, Virginia Amador
Jun 20, 2012·Cancer Control : Journal of the Moffitt Cancer Center·Bijal D ShahEduardo M Sotomayor
Jun 19, 2019·Therapeutic Advances in Medical Oncology·Zhi YangZhenxiao Jin
Sep 2, 2016·Journal of Biosciences·Sebastian John, Rashmi Mishra
Aug 21, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Milad AshrafizadehMasoud Najafi

❮ Previous
Next ❯

Methods Mentioned

BETA
flow cytometry
transfection
Chip

Software Mentioned

BDPC
Expression Console
Affymetrix
BiQ Analyzer
Command Console
Ingenuity Pathway Analysis ( IPA
Gene Chip
MethPrimer
GRANTA

Related Concepts

Related Feeds

B cells: Gene Expression

B lymphocytes are white blood cells that play a role in the adaptive immune system by secreting antibodies. Here is the latest research on gene expression in B cells.

B-Cell Leukemia (Keystone)

B-cell leukemia includes various types of lymphoid leukemia that affect B cells. Here is the latest research on B-cell leukemia.

Cancer Genomics (Keystone)

Cancer genomics approaches employ high-throughput technologies to identify the complete catalog of somatic alterations that characterize the genome, transcriptome and epigenome of cohorts of tumor samples. Discover the latest research using such technologies in this feed.

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.

Cancer Epigenetics & Metabolism (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. This feed focuses on the relationship between cell metabolism, epigenetics and tumor differentiation.

Cell Cycle Pathways

Cell cycle is a complex process regulated by several signal transduction pathways and enzymes. Here is the latest research on regulation of cell cycle and cell cycle pathways.

Cancer Epigenetics and Senescence (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may be involved in regulating senescence in cancer cells. This feed captures the latest research on cancer epigenetics and senescence.