SOX2 as a novel marker to predict neoplastic progression in Barrett's esophagus

The American Journal of Gastroenterology
Sophie van OlphenLeendert H J Looijenga

Abstract

The value of Barrett's esophagus (BE) surveillance based on the histological diagnosis of low-grade dysplasia (LGD) remains debated given the lack of adequate risk stratification. The aim of this study was to evaluate the predictive value (PV) of SOX2 expression for neoplastic progression in BE patients. We conducted a case-control study within a prospective cohort of 720 BE patients. Patients with neoplastic progression, defined as the development of high-grade dysplasia (HGD) or esophageal adenocarcinoma (EAC), were classified as cases and patients without neoplastic progression were classified as controls. SOX2 expression was determined by immunohistochemistry in more than 12,000 biopsies from 635 patients; these results were combined with our previous p53 immunohistochemical data. Nondysplastic BE showed homogeneous nuclear staining for SOX2, whereas SOX2 was progressively lost in dysplastic BE. Loss of SOX2 was seen in only 2% of biopsy series without dysplasia, in contrast to 28% in LGD and 67% in HGD/EAC. Loss of SOX2 expression was associated with an increased risk of neoplastic progression in BE patients after adjusting for gender, age, BE length, and esophagitis (adjusted relative risk 4.8; 95% CI 3.2-7.0). The positi...Continue Reading

References

Dec 22, 1999·The American Journal of Gastroenterology·J K DiBaise
Dec 22, 1999·The American Journal of Gastroenterology·J K DiBaise
Jan 11, 2001·The American Journal of Gastroenterology·M SkacelJ R Goldblum
Oct 18, 2005·Nature Reviews. Molecular Cell Biology·Michele Boiani, Hans R Schöler
Nov 3, 2005·Nature Clinical Practice. Gastroenterology & Hepatology·Navtej S Buttar, Kenneth K Wang
Dec 14, 2005·Gastroenterology·Jukka RonkainenLars Agréus
Nov 10, 2006·Nature·Jianlong WangStuart H Orkin
Mar 18, 2008·The American Journal of Gastroenterology·Kenneth K WangUNKNOWN Practice Parameters Committee of the American College of Gastroenterology
Aug 13, 2008·Journal of the National Cancer Institute·Linda Morris BrownWong-Ho Chow
Jul 30, 2009·The American Journal of Gastroenterology·Marjolein SikkemaErnst J Kuipers
Sep 1, 2009·Human Pathology·Kevin B Long, Jason L Hornick
Oct 24, 2009·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Marjolein SikkemaErnst J Kuipers
May 13, 2010·The American Journal of Gastroenterology·Wouter L CurversJacques J G H M Bergman
Mar 8, 2011·Gastroenterology·Stuart J SpechlerUNKNOWN American Gastroenterological Association
Apr 5, 2011·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Theresia WilbertzSven Perner
May 18, 2011·The American Journal of Gastroenterology·M SikkemaP D Siersema
Oct 15, 2011·The New England Journal of Medicine·Frederik Hvid-JensenPeter Funch-Jensen
Aug 1, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A P Thrift, D C Whiteman
Feb 19, 2013·Cellular Signalling·Kuancan LiuXiaopeng Lan
Oct 30, 2013·Gut·Rebecca C FitzgeraldUNKNOWN British Society of Gastroenterology
Mar 29, 2014·JAMA : the Journal of the American Medical Association·K Nadine PhoaJacques J G H M Bergman
May 17, 2014·Annals of Surgical Oncology·Judith HoningJohn Th M Plukker
Jun 24, 2014·Nature Genetics·Jamie M J WeaverUNKNOWN OCCAMS consortium
Dec 1, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A P Thrift, D C Whiteman

❮ Previous
Next ❯

Citations

Oct 22, 2016·Disease Markers·Rita BarrosPaula Chaves
Aug 27, 2017·Virchows Archiv : an International Journal of Pathology·Bruno Tavares SedassariSuzana Cantanhede Orsini Machado de Sousa
Apr 27, 2018·The American Journal of Surgical Pathology·Fiebo J C Ten KateUNKNOWN ProBar study group and Palga Group
Oct 21, 2016·Frontline Gastroenterology·David GrahamLaurence B Lovat
Jul 12, 2017·The British Journal of Surgery·F J C Ten KateK Biermann
Jun 28, 2018·Digestive Diseases and Sciences·Ramon U Jin, Jason C Mills
Nov 25, 2020·The American Journal of Gastroenterology·Nicola F FreiJacques J G H M Bergman
May 14, 2021·The American Journal of Gastroenterology·Nicola F FreiJacques J G H M Bergman
Nov 4, 2021·Nature Reviews. Gastroenterology & Hepatology·Melissa SchmidtTrevor A Graham

❮ Previous
Next ❯

Related Concepts

Related Feeds

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

Barrett Esophagus

Barrett’s esophagus if a serious complication of gastroesophageal reflux disease during which the normal esophageal lining changes to tissue that resembles intestinal lining. Here is the latest research.