SOX4 induces tumor invasion by targeting EMT-related pathway in prostate cancer

Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
Yifan LiuZhengming Su

Abstract

SOX4 (sex-determining region Y-related high-mobility group box 4) is associated with tumor progression and poor clinical outcome in several cancers. This study aims to evaluate whether SOX4 affects the biological behaviors of prostate cancer and further elucidate whether this effect works through the epithelial-mesenchymal transition pathway. We investigated the expression of SOX4 in a series of prostate cancer tissues and adjacent noncancerous tissues, as well as in a panel of prostate cancer cell lines. Cell proliferation, migration, and invasion were evaluated in SOX4 knockdown prostate cancer cell lines by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide and Transwell assay. Our results showed that the expression of SOX4 was remarkably upregulated both in prostate cancer tissues and in cell lines. Knockdown of SOX4 repressed the ability of cell proliferation and migration of DU145 cells. Moreover, inhibition of SOX4 could reverse the epithelial-mesenchymal transition processes through upregulation of E-cadherin and downregulation of vimentin. This study provided evidence that SOX4 could serve as a potential therapeutic target in prostate cancer.

References

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Citations

Oct 28, 2019·The Journal of Pathology·Yi ZhangHonghe Zhang
Jun 12, 2018·Current Molecular Biology Reports·Katia RuggeroAlvaro Aytes
Sep 16, 2020·Technology in Cancer Research & Treatment·Guolong LiaoYing Liu
Aug 7, 2019·Neoplasia : an International Journal for Oncology Research·Huyen Trang Ha ThiSuntaek Hong
May 14, 2021·Biology of Reproduction·Elisa T ZhangJulie C Baker

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Methods Mentioned

BETA
surgical resection
electrophoresis
transfection

Software Mentioned

SPSS
Quantity One

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