Sox4 is involved in osteoarthritic cartilage deterioration through induction of ADAMTS4 and ADAMTS5

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
Yoshifumi TakahataRiko Nishimura

Abstract

Osteoarthritis is a common disease in joint cartilages. Because the molecular pathogenesis of osteoarthritis remains elusive, early diagnostic markers and effective therapeutic agents have not been developed. To understand the molecular mechanisms, we attempted to identify transcription factors involved in the onset of osteoarthritis. Microarray analysis of mouse articular cartilage cells indicated that retinoic acid, a destructive stimulus in articular cartilage, up-regulated expression of sex-determining region Y-box (Sox)4, a SoxC family transcription factor, together with increases in Adamts4 and Adamts5, both of which are aggrecanases of articular cartilages. Overexpression of Sox4 induced a disintegrin-like and metallopeptidase with thrombospondin type 4 and 5 motif (ADAMTS4 and ADAMTS5, respectively) expression in chondrogenic cell lines C3H10T1/2 and SW1353. In addition, luciferase reporter and chromatin immunoprecipitation assays showed that Sox4 up-regulated ADAMTS4 and Adamts5 gene promoter activities by binding to their gene promoters. Another SoxC family member, Sox11, evoked similar effects. To evaluate the roles of Sox4 and Sox11 in articular cartilage destruction, we performed organ culture experiments using mou...Continue Reading

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Citations

Feb 23, 2020·International Journal of Molecular Sciences·Riko NishimuraLerdluck Ruengsinpinya
Jun 5, 2019·Nature Communications·Sho MokudaHiroshi Asahara
Jun 13, 2020·Journal of Cellular and Molecular Medicine·Hyemi LeeLi-Jung Kang
Sep 18, 2020·Biology·Margot NeefjesPeter M van der Kraan
Feb 10, 2021·Bone & Joint Research·Chao Peng HeChi Ma
Mar 20, 2021·Journal of Medicinal Food·Emad A AhmedHany Ezzat Khalil
Apr 4, 2021·International Journal of Molecular Sciences·Maria Teresa ValentiMonica Mottes
May 20, 2021·Journal of Orthopaedic Surgery and Research·Guo LiJiQiang Duan
Aug 27, 2021·Frontiers in Molecular Biosciences·Lejian JiangMao Lin

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