SOX7 and SOX17 regulate the parietal endoderm-specific enhancer activity of mouse laminin alpha1 gene

The Journal of Biological Chemistry
Tomoaki NiimiKiyotoshi Sekiguchi

Abstract

Laminin-1 is the major component of embryonic basement membrane and consists of alpha1, beta1, and gamma1 chains. The expression of laminin-1 is induced in mouse F9 embryonal carcinoma cells upon differentiation into parietal endoderm cells. We recently identified a parietal endoderm-specific enhancer in the mouse laminin alpha1 (Lama1) gene and showed that Sp1/Sp3 and YY1 transcription factors were involved in the enhancer activity. Although here we identified that NF-Y binds to the enhancer sequence between Sp1/Sp3- and YY1-binding sites, all these transcription factors are ubiquitously expressed and thus are not sufficient to explain parietal endoderm-specific enhancer activity. In the present study, we further showed that SOX7 and SOX17 are involved in the regulation of parietal endoderm-specific enhancer activity of the mouse Lama1 gene. Northern blot analysis revealed that the steady-state levels of mouse Sox7 and Sox17 mRNAs increased in parallel with that of Lama1 mRNA during the differentiation of F9 cells. Both SOX7 and SOX17 markedly trans-activated the transcription of the Lama1 enhancer-reporter construct in undifferentiated F9 cells in a manner dependent on high mobility group box-mediated DNA binding. Electrophor...Continue Reading

References

Nov 10, 1992·Biochemistry·J Engel
Feb 1, 1990·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·K BeckJ Engel
Dec 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·G W VasiosL J Gudas
Aug 1, 1994·Matrix Biology : Journal of the International Society for Matrix Biology·R Timpl, J C Brown
Apr 1, 1994·Matrix Biology : Journal of the International Society for Matrix Biology·R E BurgesonJ Sanes
Feb 1, 1997·Biochemical Society Transactions·K H RoderM Schweizer
Jan 13, 1998·Nature Genetics·E M Southard-SmithW J Pavan
Feb 14, 1998·Nature Genetics·V PingaultM Goossens
Apr 4, 1998·Nucleic Acids Research·R Mantovani
Jun 5, 1998·Trends in Biochemical Sciences·S N Maity, B de Crombrugghe
Feb 12, 1999·Nucleic Acids Research·S MertinV R Harley
Feb 26, 1999·Nucleic Acids Research·M Wegner
May 13, 1999·Nature Genetics·W BiB de Crombrugghe
May 13, 1999·Biochimica Et Biophysica Acta·K TaniguchiS Aiso
Dec 10, 1999·Experimental Cell Research·K Matuoka, K Yu Chen
Dec 23, 1999·Matrix Biology : Journal of the International Society for Matrix Biology·M FalkP Ekblom
Mar 24, 2000·Trends in Genetics : TIG·Y KamachiH Kondoh
Dec 29, 2000·International Review of Cytology·D ClementsH R Woodland
Jul 9, 2002·Current Opinion in Genetics & Development·Megan Wilson, Peter Koopman

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Citations

Aug 21, 2009·Cell and Tissue Research·Madeleine Durbeej
Sep 13, 2011·Proceedings of the National Academy of Sciences of the United States of America·Olivier GanierMarcel Méchali
Dec 5, 2008·Acta Crystallographica. Section F, Structural Biology and Crystallization Communications·Calista Keow Leng NgPrasanna R Kolatkar
Feb 25, 2009·Development, Growth & Differentiation·Xue-Bin QuShu-Yang Huang
Feb 12, 2009·Molecular Cancer Research : MCR·Matthew B PalmerJeremy M Boss
Oct 29, 2014·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Manuel ViottiAnna-Katerina Hadjantonakis
Oct 13, 2012·Annual Review of Cell and Developmental Biology·Anna DomogatskayaKarl Tryggvason
Mar 31, 2009·Journal of Molecular Biology·Paaventhan PalasingamPrasanna R Kolatkar
Sep 8, 2009·The International Journal of Biochemistry & Cell Biology·Mathias FrancoisMonica Beltrame
Jan 12, 2007·Genesis : the Journal of Genetics and Development·Yasuhide YoshiokaMasamitsu Yamaguchi
Feb 1, 2008·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Yasuhide YoshiokaMasamitsu Yamaguchi
Jun 3, 2008·Journal of Neuroscience Research·Eduardo Martinez-Ceballos, Lorraine J Gudas
Aug 16, 2005·Genesis : the Journal of Genetics and Development·F AlpyO Lefebvre
Sep 30, 2005·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Chi ZhangMichael W Klymkowsky
Oct 18, 2015·BMC Developmental Biology·Masaki KinoshitaHitoshi Niwa
Mar 29, 2007·Reproduction, Fertility, and Development·Janet Rossant
May 14, 2009·Journal of Neuroscience Research·Li-Jin Chew, Vittorio Gallo
Jun 5, 2008·Physiological Genomics·Ethan S PattersonJohn D Gearhart
May 15, 2018·International Journal of Molecular Sciences·Yumeng ZhangGuangchao Sui
Dec 19, 2006·Matrix Biology : Journal of the International Society for Matrix Biology·Renata MeszarosPeter Ekblom
Dec 17, 2008·Molecular and Cellular Endocrinology·Laia Navarro-MartínFrancesc Piferrer

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