SOX7 Target Genes and Their Contribution to Its Tumor Suppressive Function

International Journal of Molecular Sciences
Yumeng ZhangGuangchao Sui

Abstract

SOX7 is a transcription factor and acts as a tumor suppressor, but its target genes in cancers are poorly explored. We revealed SOX7-mediated gene expression profile in breast cancer cells using microarray chips and discovered multiple altered signaling pathways. When combinatorially analyzing the microarray data with a gene array dataset from 759 breast cancer patients, we identified four genes as potential targets of SOX7 and validated them by quantitative PCR and chromatin immunoprecipitation assays. Among these four genes, we determined that SOX7-activated SPRY1 and SLIT2, and SOX7-repressed TRIB3 and MTHFD2 could all differentially contribute to SOX7-mediated tumor suppression. Overall, we identified multiple cancer-related pathways mediated by SOX7 and for the first time revealed SOX7-regulated target genes in a cancer-relevant context.

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Citations

Jan 11, 2020·Frontiers in Pharmacology·Ruizheng SunZheng Li
May 16, 2020·Frontiers in Oncology·Zhiyuan Zhu, Gilberto Ka Kit Leung
Dec 15, 2020·Drug Discovery Today·Chengcan YangLiang Ouyang
Dec 22, 2020·Frontiers in Cell and Developmental Biology·Liming YuChao Deng
Mar 19, 2021·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Kyoung-Ok HongSeong-Doo Hong
Jul 1, 2021·World Journal of Clinical Oncology·Alejandro EspañolMaría Elena Sales

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Datasets Mentioned

BETA
GSE111122

Methods Mentioned

BETA
chips
gene
PCR
ChIP
PCRs
gene array
Immunoprecipitation
Assay

Software Mentioned

Tfsitescan
Ingenuity Systems
SigmaStat
Genewiz

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