SOX9 in cartilage development and disease

Current Opinion in Cell Biology
Véronique LefebvreAbdul Haseeb

Abstract

SOX9 is a pivotal transcription factor in chondrocytes, a lineage essential in skeletogenesis. Its mandatory role in transactivating many cartilage-specific genes is well established, whereas its pioneer role in lineage specification, which along with transactivation defines master transcription factors, remains to be better defined. Abundant, but yet incomplete evidence exists that intricate molecular networks control SOX9 activity during the multi-step chondrogenesis pathway. They include a highly modular genetic regulation, post-transcriptional and post-translational modifications, and varying sets of functional partners. Fully uncovering SOX9 actions and regulation is fundamental to explain mechanisms underlying many diseases that directly or indirectly affect SOX9 activities and to design effective disease treatments. We here review current knowledge, highlight recent discoveries, and propose new research directions to answer remaining questions.

Citations

Feb 20, 2020·International Journal of Molecular Sciences·Hideka SaotomeMasafumi Inui
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Aug 29, 2020·Artificial Cells, Nanomedicine, and Biotechnology·Azizeh Rahmani Del BakhshayeshAli Abedelahi
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Jan 16, 2021·Journal of Orthopaedic Surgery and Research·Jianmin XueXuejun Yang
Dec 9, 2020·International Journal of Molecular Sciences·Jolanta SzenajchLuiza Handschuh
Feb 19, 2021·Proceedings of the National Academy of Sciences of the United States of America·Abdul HaseebVéronique Lefebvre
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