SOX9/miR-130a/CTR1 axis modulates DDP-resistance of cervical cancer cell

Cell Cycle
Chenzhe FengYeqian Feng

Abstract

Cisplatin (DDP) -based chemotherapy is a standard strategy for cervical cancer, while chemoresistance remains a huge challenge. Copper transporter protein 1 (CTR1), a copper influx transporter required for high affinity copper (probably reduced Cu I) transport into the cell, reportedly promotes a significant fraction of DDP internalization in tumor cells. In the present study, we evaluated the function of CTR1 in the cell proliferation of cervical cancer upon DDP treatment. MicroRNAs (miRNAs) have been regarded as essential regulators of cell proliferation, apoptosis, migration, as well as chemoresistance. By using online tools, we screened for candidate miRNAs potentially regulate CTR1, among which miR-130a has been proved to promote cervical cancer cell proliferation through targeting PTEN in our previous study. In the present study, we investigated the role of miR-130a in cervical cancer chemoresistance to DDP, and confirmed the binding of miR-130a to CTR1. SOX9 also reportedly act on cancer chemoresistance. In the present study, we revealed that SOX9 inversely regulated miR-130a through direct targeting the promoter of miR-130a. Consistent with previous studies, SOX9 could affect cervical cancer chemoresistance to DDP. Take...Continue Reading

References

Sep 1, 1989·Current Problems in Cancer·R F Ozols, S D Williams
May 1, 1984·Annals of Internal Medicine·P J Loehrer, L H Einhorn
Nov 14, 2006·Biochemical Pharmacology·Jochen ZisowskyUlrich Jaehde
Nov 11, 2008·Molecular Pharmacology·Christopher A LarsonStephen B Howell
Apr 15, 2011·Molecular Cancer·Ewan A GibbWan L Lam
Aug 9, 2011·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Yanjie WengChangyu Wang
Nov 5, 2011·Applied Biochemistry and Biotechnology·Yukio NakamuraJohn H Postlethwait
Jan 17, 2012·Cancer Research·Ander MatheuRobin Lovell-Badge
May 4, 2012·Metallomics : Integrated Biometal Science·Xiubo DuHongzhe Sun
Jul 24, 2012·Biochemical Society Transactions·Ross M Drayton
Sep 27, 2012·Journal of Inorganic Biochemistry·Ganna V KalaydaUlrich Jaehde
Nov 10, 2012·Experimental Cell Research·Lynn M PouliotMichael M Gottesman
Jul 12, 2013·Biology of Reproduction·Elanor N WainwrightDagmar Wilhelm
May 6, 2014·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Eric S KimZahid H Siddik
May 17, 2014·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·G TsoucalasM Sgantzos
May 31, 2014·Cell Death & Disease·L GalluzziG Kroemer
Apr 22, 2015·Cancer Chemotherapy and Pharmacology·Jianli ChenHenry Simpkins
Feb 16, 2016·Expert Opinion on Therapeutic Targets·Laura Garros-RegulezAnder Matheu
Jun 30, 2016·Drug Design, Development and Therapy·Haiyan ZhuXueqiong Zhu
Dec 16, 2016·International Journal of Molecular Sciences·Armin ZebischHeinz Sill
Mar 10, 2017·Genes·Duncan Ayers, Jo Vandesompele

❮ Previous
Next ❯

Citations

Jun 20, 2020·Expert Opinion on Therapeutic Targets·Shanshan WangGeorge G Chen
Oct 21, 2020·International Journal of Molecular Sciences·Sabine StöcklSusanne Grässel
Dec 15, 2020·European Journal of Pharmacology·Milad AshrafizadehMasoud Najafi
Feb 2, 2021·Biochimica Et Biophysica Acta. Reviews on Cancer·Munmun PandaBijesh K Biswal
Apr 20, 2021·Frontiers in Immunology·Xueqin ZouQixiang Shao
May 7, 2021·International Journal of Biological Macromolecules·Milad AshrafizadehMichael R Hamblin
Aug 29, 2021·Molecular and Cellular Biochemistry·Tandrima Mitra, Selvakumar Elangovan
Feb 4, 2022·Cellular and Molecular Life Sciences : CMLS·Matheus Lohan-CodeçoAntonio Palumbo

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR
immunoprecipitation
transfection
ChIP
surgical resection
ChIP-PCR

Software Mentioned

Jaspar
miRWalk
Targetscan
miRanda
RNA22
SPSS

Related Concepts

Related Feeds

Cell Migration in Cancer and Metastasis

Migration of cancer cells into surrounding tissue and the vasculature is an initial step in tumor metastasis. Discover the latest research on cell migration in cancer and metastasis here.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.