Soy Intake and Colorectal Cancer Risk: Results from a Pooled Analysis of Prospective Cohort Studies Conducted in China and Japan.

The Journal of Nutrition
Nikhil K KhankariWei Zheng

Abstract

Soy is commonly consumed in east Asian countries and is suggested to reduce colorectal cancer (CRC) risk. However, results from epidemiologic studies are inconsistent, despite the anti-inflammatory and antiproliferative properties of soy isoflavones and soy protein. We evaluated the association between soy isoflavones and soy protein and CRC risk using 4 prospective cohort studies from China and Japan. Data were pooled from the Shanghai Women's Health Study (SWHS), Shanghai Men's Health Study (SMHS), Japan Public Health Center-based Prospective Study Cohort 1 (JPHC1), and Cohort 2 (JPHC2). Cox proportional hazards models estimated HRs and corresponding 95% CIs for the association of soy protein and isoflavone intake with CRC risk. The study included 205,060 individuals, among whom 2971 were diagnosed with incident CRC over an average follow-up of 12.7 y. No statistically significant associations with CRC risk were observed for soy protein or isoflavone intake. No association was observed among ever smokers consuming higher isoflavones (HRisoflavones: 0.83; 95% CI: 0.68, 1.00) and soy protein (HRsoy protein: 0.81; 95% CI: 0.39, 1.10). However, risk reductions were observed among premenopausal women with a body mass index [BMI (k...Continue Reading

References

Nov 1, 1987·Gastroenterology·S J StrykerR L MacCarty
Oct 23, 1998·Journal of Epidemiology·M KimiraS Watanabe
Jul 5, 2001·Gastroenterology·J C HardwickM P Peppelenbosch
Aug 21, 2001·Journal of the American Academy of Dermatology·L R Nelson, S E Bulun
Jan 28, 2003·Journal of Molecular Biology·Emmanuel MargeatCatherine Royer
Jun 7, 2003·The American Journal of Clinical Nutrition·Ligia Zubik, Mohsen Meydani
Dec 11, 2003·Journal of Agricultural and Food Chemistry·Drazen KostelacKarlis Briviba
Oct 21, 2005·American Journal of Epidemiology·Wei ZhengYu-Tang Gao
Sep 13, 2006·Nutrition and Cancer·Mark MessinaAnna H Wu
Mar 6, 2007·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Norie KurahashiUNKNOWN Japan Public Health Center-Based Prospective Study Group
Mar 27, 2007·The British Journal of Nutrition·Raquel VillegasXiao Ou Shu
Jun 19, 2007·Nutrition and Cancer·Shino ObaShogen Matsushita
May 10, 2008·Archives of Physiology and Biochemistry·Andrew G RenehanCaroline Dive
Aug 19, 2008·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Munira AkhterUNKNOWN Japan Public Health Center-Based Prospective Study Group
Sep 25, 2008·British Journal of Cancer·L M ButlerM C Yu
Dec 17, 2008·The American Journal of Clinical Nutrition·Gong YangWei Zheng
Oct 15, 2009·Annual Review of Medicine·Darren L RobertsAndrew G Renehan
Jun 4, 2010·The Journal of Nutrition·Kenneth D R Setchell, Carlo Clerici
Oct 26, 2010·Scandinavian Journal of Gastroenterology·Sanjeev BudhathokiReiji Terasaka
May 23, 2012·Climacteric : the Journal of the International Menopause Society·E L Barnes, M D Long
Aug 15, 2012·Journal of Nutrition in Gerontology and Geriatrics·Ock K ChunWon O Song
Dec 25, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·María José García-NebotBlanca Hernández-Ledesma
Aug 12, 2014·Japanese Journal of Clinical Oncology·Shoichiro Tsugane, Norie Sawada
Mar 4, 2015·International Journal of Epidemiology·Xiao-Ou ShuYong-Bing Xiang
Sep 15, 2015·European Journal of Gastroenterology & Hepatology·Yaron Niv
Jun 15, 2016·Nutrients·Jie YuDaiwen Chen
Jan 17, 2017·The British Journal of Nutrition·Ruijingfang JiangJenny Chang-Claude
Oct 11, 2017·Journal of the Science of Food and Agriculture·Chia-Chien HsiehBlanca Hernández-Ledesma

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