Soy Isoflavones Ameliorate Fatty Acid Metabolism of Visceral Adipose Tissue by Increasing the AMPK Activity in Male Rats with Diet-Induced Obesity (DIO)

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Jinlong TanZhengli Chen

Abstract

Soy isoflavones are natural active ingredients of soy plants that are beneficial to many metabolic diseases, especially obesity. Many studies have reported that obesity is closely related to visceral fatty acid metabolism, but the effect has not been well defined. In this study, we show that soy isoflavones improve visceral fatty acid metabolism in diet-induced obese male rats, which was indicated by reduced body weight and visceral fat cell area, as well as suppressed visceral fat synthesis and accelerated fat hydrolysis. We also found that common components of soy isoflavones, daidzein and genistein, were able to inhibit the lipid accumulation process in 3T3-L1 cells. Moreover, we showed that soy isoflavones can promote on AMP-activated protein kinase (AMPK) activity both in vivo and in vitro, which may be implicated in lipid metabolism regulation of soy isoflavones. Our study demonstrates the potential of soy isoflavones as a mechanism for regulating lipid homeostasis in visceral adipose tissue, proven to be beneficial for obesity treatment.

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Citations

Mar 4, 2020·International Journal of Molecular Sciences·Madhulika TripathiBrijesh Kumar Singh
Jun 5, 2020·Nutrients·Edson de Andrade PessoaFernanda Teixeira Borges
Jun 20, 2020·Clinical Science·Manal Muin FardounAli H Eid
May 1, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yae Rim ChoiMin Jung Kim
May 31, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Meenakshi Sudhakaran, Andrea I Doseff
Jan 5, 2021·Journal of Nutritional Science and Vitaminology·Shiho NakaiYasutomi Kamei
Jan 1, 2021·International Journal of Molecular Sciences·Alina Kuryłowicz
Jun 12, 2021·Revista española de geriatría y gerontología·Cristina Chávez-PérezAbel Suárez-Castro

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Image Pro Plus
Statistical Program for Social Sciences software ( SPSS
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