Soy isoflavones improve systemic arterial compliance but not plasma lipids in menopausal and perimenopausal women

Arteriosclerosis, Thrombosis, and Vascular Biology
P J NestelM Abbey

Abstract

The possibility that the heightened cardiovascular risk associated with the menopause, which is said to be ameliorated by soybeans, can be reduced with soy isoflavones was tested in 21 women. Although several were perimenopausal, all have been included. A placebo-controlled crossover trial tested the effects of 80-mg daily isoflavones (45 mg genistein) over 5- to 10-week periods. Systemic arterial compliance (arterial elasticity), which declined with age in this group, improved 26% (P < .001) compared with placebo. Arterial pressure and plasma lipids were unaffected. The vasodilatory capacity of the microcirculation was measured in nine women; high acetylcholine-mediated dilation in the forearm vasculature was similar with active and placebo treatments. LDL oxidizability measured in vitro was unchanged. Thus, one important measure of arterial health, systemic arterial compliance, was significantly improved in perimenopausal and menopausal women taking soy isoflavones to about the same extent as is achieved with conventional hormone replacement therapy.

References

Jan 1, 1978·Methods in Enzymology·J A Buege, S D Aust
Apr 10, 1991·JAMA : the Journal of the American Medical Association·E Barrett-Connor, T L Bush
Oct 1, 1986·The American Journal of Physiology·V E Baracos, A L Goldberg
Apr 30, 1987·The New England Journal of Medicine·G A ColditzC H Hennekens
May 1, 1985·Biochemical Pharmacology·H C JhaF Zilliken
Aug 1, 1983·The American Journal of Clinical Nutrition·S M Grundy, J J Abrams
Aug 3, 1995·The New England Journal of Medicine·J W AndersonM E Cook-Newell
Dec 15, 1994·Annals of Internal Medicine·E H LiebermanM A Creager
Sep 1, 1994·The American Journal of Clinical Nutrition·A CassidyK D Setchell
Aug 1, 1997·Journal of the American College of Cardiology·C RajkumarA M Dart

❮ Previous
Next ❯

Citations

Feb 24, 2001·BioFactors·S BarnesJ Xu
Oct 17, 2001·Current Atherosclerosis Reports·K D Hecker
Dec 21, 2000·Current Atherosclerosis Reports·A H Lichtenstein
Apr 1, 2010·Indian Journal of Clinical Biochemistry : IJCB·H K JassiR Chitra
Mar 18, 1987·Biochimica Et Biophysica Acta·K Alexander, S I Baskin
Sep 15, 2004·Fertility and Sterility·UNKNOWN Practice Committee of the American Society for Reproductive Medicine
Jun 23, 2004·Maturitas·Tamara M Knudson SchultJeffrey A Tice
Jun 1, 2000·The American Journal of Cardiology·L A SimonsD S Celermajer
Sep 17, 1999·Atherosclerosis·P MottramP Nestel
Feb 18, 1999·Toxicology Letters·L StraussS Mäkelä
Feb 28, 2002·Journal of Pharmaceutical and Biomedical Analysis·T NurmiH Adlercreutz
Mar 27, 2001·Journal of the American College of Cardiology·A M Dart, B A Kingwell
Jan 29, 2003·The Journal of Nutritional Biochemistry·Isabelle DemontyHélène Jacques
Nov 1, 2000·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M Messina
Jun 6, 2003·Best Practice & Research. Clinical Endocrinology & Metabolism·Alison M DuncanMindy S Kurzer
Aug 10, 2012·The British Journal of Nutrition·Mark MessinaDavid J A Jenkins
Jun 20, 2002·Clinical Endocrinology·Georgina HaleC Noel Bairey Merz
Dec 21, 2002·Asia Pacific Journal of Clinical Nutrition·Karen E Charlton
Nov 16, 2001·Asia Pacific Journal of Clinical Nutrition·L RidgesP Howe
Nov 13, 2002·Kidney International·Masahiko TozawaShuichi Takishita
Jun 1, 1999·Nutrition Research Reviews·J J AndersonS C Garne

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.