Soya protein β-conglycinin ameliorates fatty liver and obesity in diet-induced obese mice through the down-regulation of PPARγ

The British Journal of Nutrition
Dongyang LiTomomi Yamazaki

Abstract

Diets high in fat can result in obesity and non-alcoholic fatty liver disease (NAFLD). The improvement of obesity and NAFLD is an important issue. β-Conglycinin, one of the soya proteins, is known to prevent hyperlipidaemia, obesity and NAFLD. Therefore, we aimed to investigate the effects of β-conglycinin on the improvement of obesity and NAFLD in high-fat (HF) diet-induced obese (DIO) mice and clarify the mechanism underlying these effects in liver and white adipose tissue (WAT). DIO male ddY mice were divided into six groups: HF, medium-fat (MF) and low-fat (LF) groups fed casein, and HF, MF and LF groups in all of which the casein was replaced by β-conglycinin. A period of 5 weeks later, the β-conglycinin-supplemented group resulted in lower body weight, relative weight of subcutaneous WAT, and hepatic TAG content (P=0·001). Furthermore, β-conglycinin suppressed the hepatic expression of Pparγ2 in the HF dietary group, sterol regulatory element-binding protein-1c and the target genes. The expressions of inflammation-related genes were significantly low in the epididymal and subcutaneous WAT from the mice fed β-conglycinin compared with those fed casein in the HF dietary group. Moreover, the expressions of Pparγ1 and Pparγ2 ...Continue Reading

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Citations

Feb 9, 2019·Journal of Enzyme Inhibition and Medicinal Chemistry·Vanessa Cristina Oliveira de LimaAna Heloneida de Araújo Morais
Dec 21, 2018·International Journal of Molecular Sciences·Tomomi YamazakiReina Ikaga
Jan 7, 2020·Journal of Nutritional Science and Vitaminology·Hirokazu TaniguchiKengo Ishihara
Feb 23, 2021·Chronobiology International·Dongyang LiTomomi Yamazaki
May 1, 2021·Nutrients·Andrea MegaAnnarosa Floreani
Jun 3, 2021·Marine Drugs·Tomomi YamazakiReina Ikaga

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