Soybean-Hop Alleviates Estrogen Deficiency-Related Bone Loss and Metabolic Dysfunction in Ovariectomized Rats Fed a High-Fat Diet

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Dasom NohOran Kwon

Abstract

Soybeans and hops have been traditionally used as a natural estrogen replacement therapy and their major active ingredients, isoflavones and prenylflavanones, are known to have estrogenic/antiestrogenic effects depending on the target organ. However, their potential benefits are still subject to controversies. The present study investigated the dual effect of soy isoflavones plus hop prenylflavanones (Soy-Hop) on bone loss and metabolic dysfunction under estrogen deficient condition. Rats were sham-operated (n = 10) or ovariectomized (OVX; n = 40) and then fed a high-fat diet (HFD) to develop hyperlipidemia in OVX rats within the experimental period of 8 weeks. The OVX/HFD rats were assigned to four groups to receive different doses of Soy-Hop (0, 30, 100, and 300 mg/kg) by oral gavage for 8 weeks. High-dose Soy-Hop significantly suppressed OVX/HFD-induced increases in food intake, body weight gain, fat mass, and circulating levels of leptin, adiponectin, LDL-cholesterol, total cholesterol, triglycerides, glucose, and insulin. High-dose Soy-Hop also attenuated OVX/HFD-induced elevation of osteocalcin, alkaline phosphatase, and CTX in plasma and RANKL/OPG gene expression ratio in femur. These findings were confirmed visually by ...Continue Reading

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Citations

Jan 15, 2021·Food & Function·Jie QiaoYuezhong Ren
Jun 3, 2021·Nutrients·Wojciech SłupskiBeata Nowak
Jul 3, 2021·International Journal of Molecular Sciences·Jose M Romero-MárquezJosé L Quiles
Dec 2, 2021·Journal of Agricultural and Food Chemistry·Xiaoling LiuDan Ohtan Wang

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Methods Mentioned

BETA
PCR
X-ray

Software Mentioned

Hop
Soy
SAS
BLAST

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