Soybean protein-derived peptide nutriment increases negative nitrogen balance in burn injury-induced inflammatory stress response in aged rats through the modulation of white blood cells and immune factors

Food & Nutrition Research
Jian ZhangXinqi Liu

Abstract

As an important nutrient, soybean protein-derived peptides (SPP) affect the immune function of animals. This study describes the effects of nutrient supplementation with SPP on the negative nitrogen balance in the burn injury-induced inflammatory response of aged rats. Soybean protein isolate (SPI) was hydrolyzed to obtain SPP. A negative nitrogen-balance aged rat model and a major full-thickness 30% total body surface area (TBSA) burn-injury rat model were utilized. The results show that SPP can increase the speed and ability of inflammatory stress by adjusting white blood cell counts. Soybean protein-derived peptides significantly increased serum immunoglobulin M (IgM), immunoglobulin G (IgG) and immunoglobulin A (IgA) levels; significantly decreased serum interleukin-1 beta (IL-β), tumor necrosis factor-alpha (TNF-α) and regulated upon activation normal T-cell expressed and secreted (RANTES) levels. These results give conclusive evidence that SPP has a significantly positive effect in improving the immune function on the condition of negative nitrogen balance with burn-injury, and reducing excessive inflammation. Nutrient supplementation of SPP can, therefore, be used as an adjuvant treatment to inhibit the development and s...Continue Reading

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Citations

May 25, 2021·Critical Reviews in Food Science and Nutrition·Yonghui YuBaoguo Sun
Aug 28, 2021·International Journal of Molecular Sciences·Il-Sup KimCheorl-Ho Kim

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Methods Mentioned

BETA
ELISA
electrophoresis
gel filtration

Software Mentioned

Graph Pad Prism
SPSS

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