PMID: 7538996Feb 1, 1995Paper

SP-induced contraction of airway smooth muscle in normal and allergen-sensitized rabbits: mechanism of action

Journal of Applied Physiology
Giuseppe N ColasurdoGary L Larsen

Abstract

We studied the mechanisms involved in the airway smooth muscle (ASM) contraction to substance P (SP) in normal (control) and allergen-sensitized (immune) rabbits as well as immune rabbits exposed to allergen via the airways (immune challenged). Cumulative concentration-response curves to SP (1 x 10(-9) to 1 x 10(-4) M) were performed in ASM segments in the absence and presence of atropine (10(-5) M) in vitro. The maximal contractile response (g tension/g tissue) at 10(-4) M SP and ASM contractions at various concentrations of SP were expressed as means +/- SE. We found no difference in the contractile response to SP between control and immune animals. ASM segments obtained from immune-challenged rabbits were more responsive to SP. Atropine shifted to the right the concentration-response curves and decreased the maximal ASM contraction at 10(-4) M SP in all three groups; this effect, however, was greater in immune-challenged tissues. These findings demonstrate an increased contractile response to SP in immune-challenged animals mediated by a more pronounced facilitation of cholinergic neurotransmission. We conclude that the final ASM response to SP is the result of a complex interaction between direct effects on ASM and indirect...Continue Reading

Citations

Jun 24, 2004·Pediatric Pulmonology·Gary L LarsenGiuseppe N Colasurdo
Apr 26, 2011·American Journal of Physiology. Lung Cellular and Molecular Physiology·Lucas W MeuchelY S Prakash

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