Sp1 control of gene expression in myeloid cells

Critical Reviews in Eukaryotic Gene Expression
Karen K Resendes, Alan G Rosmarin

Abstract

Gene transcription plays a critical role in the differentiation of myeloid cells. However, there is no single, master regulator of all myeloid genes. Rather, myeloid gene transcription is regulated by the combinatorial effects of a limited number of key transcription factors. Sp1 is a powerful activator of gene transcription in many cell types. Although it is wildly expressed, Sp1 binds and activates the promoters of a large number of important myeloid genes. This presents the paradox of how a widely expressed transcription factor can regulate lineage-specific gene transcription. This review discusses the structure, function, and expression patterns of Sp1 and its related Sp family members. Illustrative examples of the tissue-specific regulation of myeloid target genes are presented. The roles of post-translational modifications of Sp1, alterations in target gene chromatin structure, and important cooperating transcription factors are discussed. Thus, Sp1 serves as a model of how a widely expressed transcription factor regulates the expression of tissue-specific genes.

Citations

Oct 15, 2013·The International Journal of Biochemistry & Cell Biology·Hidekazu YamamotoClaudia Kemper
Dec 3, 2011·Journal of Biochemistry·Kuniaki OkamotoKenji Yamamoto
Aug 29, 2006·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Christina T Teng
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Feb 6, 2016·Experimental Hematology & Oncology·Amanda J FavreauPradeep Sathyanarayana
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