SP140L, an Evolutionarily Recent Member of the SP100 Family, Is an Autoantigen in Primary Biliary Cirrhosis

Journal of Immunology Research
Mario SaarePärt Peterson

Abstract

The SP100 family members comprise a set of closely related genes on chromosome 2q37.1. The widely expressed SP100 and the leukocyte-specific proteins SP110 and SP140 have been associated with transcriptional regulation and various human diseases. Here, we have characterized the SP100 family member SP140L. The genome sequence analysis showed the formation of SP140L gene through rearrangements of the two neighboring genes, SP100 and SP140, during the evolution of higher primates. The SP140L expression is interferon-inducible with high transcript levels in B cells and other peripheral blood mononuclear cells. Subcellularly, SP140L colocalizes with SP100 and SP140 in nuclear structures that are devoid of SP110, PML, or p300 proteins. Similarly to SP100 and SP140 protein, we detected serum autoantibodies to SP140L in patients with primary biliary cirrhosis using luciferase immunoprecipitation system and immunoblotting assays. In conclusion, our results show that SP140L is phylogenetically recent member of SP100 proteins and acts as an autoantigen in primary biliary cirrhosis patients.

References

Nov 15, 1996·The Journal of Biological Chemistry·D B BlochK D Bloch
May 9, 1998·Science·A I Lamond, W C Earnshaw
Jun 24, 1998·Proceedings of the National Academy of Sciences of the United States of America·J S SeelerA Dejean
Jun 24, 1998·Proceedings of the National Academy of Sciences of the United States of America·N LehmingM Ptashne
Nov 10, 1998·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·K E KisandR Uibo
May 18, 1999·Molecular and Cellular Biology·D B BlochK D Bloch
Jun 28, 2001·Nature Structural Biology·M J BottomleyM Sattler
Feb 20, 2003·The American Journal of Gastroenterology·Paolo MuratoriFrancesco B Bianchi
Jul 10, 2003·Autoimmunity Reviews·Howard J Worman, Jean Claude Courvalin
Feb 19, 2004·The Journal of Cell Biology·Jayson WangDenise Sheer
Mar 23, 2004·Nucleic Acids Research·Robert C Edgar
Feb 26, 2005·Journal of Cell Science·Reagan W ChingDavid P Bazett-Jones
Sep 24, 2005·The EMBO Journal·Paul D LingDonald B Bloch
Jun 16, 2006·Journal of Cellular Biochemistry·Anne IsaacJerry L Taylor
Jul 4, 2006·Molecular Phylogenetics and Evolution·Michael E Steiper, Nathan M Young
Jan 11, 2007·Journal of Microscopy·S Bolte, F P Cordelières
Mar 9, 2007·Biochimie·Roger D Everett, Mounira K Chelbi-Alix
Aug 19, 2007·Trends in Biochemical Sciences·Luis Sanchez-PulidoAna M Rojas
Oct 12, 2007·Nature Reviews. Molecular Cell Biology·Rosa Bernardi, Pier Paolo Pandolfi
Apr 22, 2008·Nucleic Acids Research·A DereeperO Gascuel
May 24, 2008·Clinical Reviews in Allergy & Immunology·Dimitrios P Bogdanos, Diego Vergani
Aug 7, 2008·Mutation Research·Lindsey A BakerGang G Wang
Sep 2, 2008·Nature Genetics·Maria Chiara Di BernardoRichard S Houlston
Nov 15, 2008·Nature Reviews. Immunology·Pärt PetersonAna Rebane
Jun 26, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Keith D LindorUNKNOWN American Association for Study of Liver Diseases
Oct 9, 2009·Journal of Visualized Experiments : JoVE·Peter D BurbeloMichael J Iadarola
Oct 29, 2009·The American Journal of Gastroenterology·Alessandro GranitoPaolo Muratori
Dec 28, 2010·Clinica Chimica Acta; International Journal of Clinical Chemistry·Dimitrios P Bogdanos, Lars Komorowski
Aug 13, 2011·Nature·UNKNOWN International Multiple Sclerosis Genetics ConsortiumAlastair Compston
Sep 13, 2011·Molecular Cell·Woong KimSteven P Gygi
Oct 4, 2011·Cell·Michael J EmanueleStephen J Elledge

❮ Previous
Next ❯

Citations

Mar 4, 2014·PLoS Pathogens·Franziska DağLuka Cičin-Šain
Dec 14, 2016·World Journal of Hepatology·Ying-Qiu Huang
Feb 19, 2021·Frontiers in Cellular and Infection Microbiology·Mila Collados Rodríguez
May 11, 2020·Trends in Immunology·Isabella Fraschilla, Kate L Jeffrey
Apr 2, 2021·Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology·Alessandro GranitoPaolo Muratori
Apr 28, 2021·The FEBS Journal·Yu-San Huoh, Sun Hur
Jun 23, 2021·JCI Insight·Kazufumi MatsushitaStephen J Galli
Feb 7, 2018·Chemical Reviews·Ibraheem AliMelanie Ott

❮ Previous
Next ❯

Datasets Mentioned

BETA
KF419367

Methods Mentioned

BETA
two-hybrid
ubiquitination
immunoprecipitation
density gradient centrifugation
PCR
fluorescence imaging
transfections
transfection
Assay

Software Mentioned

MUSCLE
Ensembl
ImageJ
Gblocks

Related Concepts

Related Feeds

B cells: Gene Expression

B lymphocytes are white blood cells that play a role in the adaptive immune system by secreting antibodies. Here is the latest research on gene expression in B cells.

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.