PMID: 11604093Oct 18, 2001Paper

Space radiation cancer risks and uncertainties for Mars missions

Radiation Research
Francis A CucinottaJ F Dicello

Abstract

Projecting cancer risks from exposure to space radiation is highly uncertain because of the absence of data for humans and because of the limited radiobiology data available for estimating late effects from the high-energy and charge (HZE) ions present in the galactic cosmic rays (GCR). Cancer risk projections involve many biological and physical factors, each of which has a differential range of uncertainty due to the lack of data and knowledge. We discuss an uncertainty assessment within the linear-additivity model using the approach of Monte Carlo sampling from subjective error distributions that represent the lack of knowledge in each factor to quantify the overall uncertainty in risk projections. Calculations are performed using the space radiation environment and transport codes for several Mars mission scenarios. This approach leads to estimates of the uncertainties in cancer risk projections of 400-600% for a Mars mission. The uncertainties in the quality factors are dominant. Using safety standards developed for low-Earth orbit, long-term space missions (>90 days) outside the Earth's magnetic field are currently unacceptable if the confidence levels in risk projections are considered. Because GCR exposures involve mult...Continue Reading

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Citations

Oct 24, 2006·Radiation and Environmental Biophysics·B M RabinV Cheng
Nov 15, 2006·Radiation and Environmental Biophysics·C L LimoliJ R Fike
Jan 27, 2007·Radiation and Environmental Biophysics·Paula V BennettBetsy M Sutherland
Mar 8, 2007·Radiation and Environmental Biophysics·Francis A CucinottaDonald M Hassler
Apr 24, 2010·Radiation and Environmental Biophysics·Walter Schimmerling
May 9, 2012·Radiation and Environmental Biophysics·Shubhankar SumanAlbert J Fornace
Nov 26, 2010·Antioxidants & Redox Signaling·John E BakerJohn W Hopewell
Oct 23, 2013·PloS One·Francis A CucinottaJanice L Huff
Dec 10, 2009·International Journal of Radiation Biology·Marta Korcyl, Michael P R Waligórski
Feb 7, 2016·Seminars in Cell & Developmental Biology·Souparno Bhattacharya, Aroumougame Asaithamby
Jul 17, 2015·Life Sciences in Space Research·Francis A CucinottaMyung-Hee Y Kim
Jan 21, 2010·Mutation Research·Francis A Cucinotta, Lori J Chappell
Jun 7, 2005·Advances in Space Research : the Official Journal of the Committee on Space Research (COSPAR)·M Durante, A Kronenberg
Jun 7, 2005·Advances in Space Research : the Official Journal of the Committee on Space Research (COSPAR)·R LeeS Ritter
May 11, 2005·Advances in Space Research : the Official Journal of the Committee on Space Research (COSPAR)·F A CucinottaJ F Dicello
May 11, 2005·Advances in Space Research : the Official Journal of the Committee on Space Research (COSPAR)·G De AngelisJ W Wilson
May 11, 2005·Advances in Space Research : the Official Journal of the Committee on Space Research (COSPAR)·G De AngelisJ W Wilson
May 11, 2005·Advances in Space Research : the Official Journal of the Committee on Space Research (COSPAR)·J W WilsonG De Angelis
May 11, 2005·Advances in Space Research : the Official Journal of the Committee on Space Research (COSPAR)·J W WilsonJ Tweed
May 2, 2006·The Lancet Oncology·Francis A Cucinotta, Marco Durante
May 9, 2013·International Journal of Radiation Biology·Gabriel S KrigsfeldAnn R Kennedy
May 4, 2015·Radiation and Environmental Biophysics·Bernard M RabinChelsea Baxter
Feb 12, 2009·Zeitschrift für medizinische Physik·Marco Durante
Sep 28, 2017·International Journal of Molecular Sciences·Elizabeth A BlaberKaren R Jonscher
Jul 17, 2003·Health Physics·John F Dicello

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