Space-time clustering analyses of type 1 diabetes in children from north-east England: support for an infectious aetiology?

Environmental Health : a Global Access Science Source
Richard J Q McNallyTim D Cheetham

Abstract

The aetiology of type 1 diabetes in children is uncertain. A number of recent studies have suggested an infectious aetiology. It has been postulated that an infectious agent may be involved. Support for this hypothesis may be provided by a finding of space-time clustering. The aims of this study were: (i) to determine whether there was space-time clustering in cases of childhood diabetes from north-east England; and to test for differences in space-time clustering: (ii) due to age at diagnosis; (iii) between the sexes and (iv) between levels of residential population density. We studied incidence of type 1 diabetes diagnosed in children aged 0-14 years and diagnosed during the period 1990-2007. All cases were resident in a defined geographical region of north-east England (Northumberland, Newcastle upon Tyne and North Tyneside). We applied a second-order procedure based on K-functions to test for global clustering. Locations were residential addresses at time of diagnosis. Tests were repeated using nearest neighbour thresholds to allow for variable population density, providing the primary result for each analysis. Differences between sexes and between levels of population density were assessed. We analysed 457 cases of type 1 ...Continue Reading

References

Dec 1, 1979·American Journal of Diseases of Children·D T Purtilo, J L Sullivan
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Oct 20, 2004·British Journal of Haematology·Richard J Q McNally, Tim O B Eden
Oct 31, 2008·Diabetes·Christophe M Filippi, Matthias G von Herrath

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Citations

Feb 5, 2010·Environmental Health : a Global Access Science Source·Michael N Moore, Pamela D Kempton
Apr 11, 2013·PloS One·Colin R MuirheadRichard J Q McNally
Oct 7, 2010·Epidemiology·Richard J Q McNallyTim D Cheetham

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