Spanish consensus on the use of natalizumab (Tysabri®)-2013

Neurología : publicación oficial de la Sociedad Española de Neurología
O FernándezX Montalbán

Abstract

Natalizumab treatment has been shown to be very efficacious in clinical trials and very effective in clinical practice in patients with relapsing-remitting multiple sclerosis, by reducing relapses, slowing disease progression, and improving magnetic resonance imaging patterns. However, the drug has also been associated with a risk of progressive multifocal leukoencephalopathy (PML). The first consensus statement on natalizumab use, published in 2011, has been updated to include new data on diagnostic procedures, monitoring for patients undergoing treatment, PML management, and other topics of interest including the management of patients discontinuing natalizumab. This updated version followed the method used in the first consensus. A group of Spanish experts in multiple sclerosis (the authors of the present document) reviewed all currently available literature on natalizumab and identified the relevant topics would need updating based on their clinical experience. The initial draft passed through review cycles until the final version was completed. Studies in clinical practice have demonstrated that changing to natalizumab is more effective than switching between immunomodulators. They favour early treatment with natalizumab r...Continue Reading

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Citations

Dec 26, 2016·Radiología·J A Guzmán-De-VilloriaP J Borrego-Ruiz
Oct 5, 2017·Cancer Control : Journal of the Moffitt Cancer Center·Chandrashekar BohraSamir Dalia
Nov 16, 2014·Current Treatment Options in Neurology·Nuria Sola-VallsAlbert Saiz
Apr 18, 2017·Brain and Behavior·Inés González-SuarezCelia Oreja-Guevara
May 15, 2018·Neurología : publicación oficial de la Sociedad Española de Neurología·A Pato PatoJ M Prieto González

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