Spanish Paediatric Infectious Diseases Society consensus document on the treatment of fungal infections based on the immune response

Anales de pediatría : publicación oficial de la Asociación Española de Pediatría (A.E.P.)
A MartínGrupo de Estudio de la Infección Fúngica Invasiva de la Sociedad Española de Infectología Pediátrica (SEIP)

Abstract

Despite the emergence of new diagnostic and therapeutic methods, invasive fungal infections are still a major cause of morbidity and mortality in immunocompromised and critical patients. Therefore, adjuvant treatments to the standard antifungal therapy are being investigated, with immunity-based therapy being one of the most important. Both immunomodulatory (dendritic and T cells transfusions, colony stimulating factors, interferón-gamma, interleukin 12, fungal vaccines, transfer factors and certain drugs such as chloroquine) and immunotherapeutic modalities (granulocyte transfusions, monoclonal antibodies and intravenous immunoglobulin) have been described. This document aims to summarise currently available data on immunity-based therapy of fungal infections and to provide basic knowledge on the immune response to fungal infections. This helps to understand how, in selected cases, immunity-based therapy may improve the response to standard antifungal treatment. The potential indications of immunity-based therapy in the paediatric patient are reviewed, although there is still a lack of scientific evidence for its use in children.

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Citations

Jan 1, 2011·Revista de psiquiatrí́a y salud mental·Francisco Javier Sanz-FuentenebroErnesto Verdura Vizcaíno
Nov 30, 2014·Revista de psiquiatrí́a y salud mental·Rosana Guerrero-DomínguezIgnacio Jiménez

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