Spanish Preanalytical Quality Monitoring Program (SEQC), an overview of 12 years' experience

Clinical Chemistry and Laboratory Medicine : CCLM
María Antonia LlopisMaría Jesús Alsina


Preanalytical variables, such as sample collection, handling and transport, may affect patient results. Preanalytical phase quality monitoring should be established in order to minimize laboratory errors and improve patient safety. A retrospective study (2001-2013) of the results obtained through the Spanish Society of Clinical Biochemistry and Molecular Pathology (SEQC) External quality assessment (preanalytical phase) was performed to summarize data regarding the main factors affecting preanalytical phase quality. Our aim was to compare data from 2006 to 2013 with a previously published manuscript assessing the 2001-2005 period. A significant decrease in rejection rates was observed both for blood and urine samples. For serum samples, the most frequent rejection causes in the first period were non-received samples (37.5%), hemolysis (29.3%) and clotted samples (14.4%). Conversely, in the second period, hemolysis was the main rejection cause (36.2%), followed by non-received samples (34.5%) and clotted samples (11.1%). For urine samples, the main rejection cause overall was a non-received sample (up to 86.1% of cases in the second period, and 81.6% in the first). For blood samples with anticoagulant, the number of rejections a...Continue Reading


Jul 18, 2003·American Journal of Clinical Pathology·Michael L AstionValerie L Ng
Sep 24, 2005·Clinical Chemistry and Laboratory Medicine : CCLM·Adolfo RomeroGemma Ramírez
Apr 8, 2006·Clinical Chemistry and Laboratory Medicine : CCLM·Giuseppe LippiMario Plebani
May 30, 2006·Clinical Chemistry and Laboratory Medicine : CCLM·Mario Plebani
Jun 21, 2007·Clinical Chemistry and Laboratory Medicine : CCLM·Mario Plebani
Jul 8, 2008·Clinical Chemistry and Laboratory Medicine : CCLM·Ma Jesús AlsinaCecília Martínez-Brú
Mar 24, 2009·Clinica Chimica Acta; International Journal of Clinical Chemistry·Giorgio Da Rin
Aug 4, 2011·Archives of Pathology & Laboratory Medicine·Raouf E NakhlehLeonas G Bekeris
Oct 26, 2012·Clinical Chemistry and Laboratory Medicine : CCLM·Wilson ShcolnikDavid Burnett
Feb 12, 2014·Clinica Chimica Acta; International Journal of Clinical Chemistry·Alberto Dolci, Mauro Panteghini
Mar 14, 2014·Clinical Chemistry and Laboratory Medicine : CCLM·Mario PlebaniZorica Sumarac
Mar 15, 2014·Biochemia Medica·Gunn B B KristensenSverre Sandberg
Jun 5, 2014·Clinical Chemistry and Laboratory Medicine : CCLM·Pilar FernandezMercè Montesinos
Jul 31, 2014·Archives of Pathology & Laboratory Medicine·Donald S Karcher, Christopher M Lehman
Feb 27, 2015·Clinical Chemistry and Laboratory Medicine : CCLM·Mario PlebaniMaria Laura Chiozza
Jul 22, 2015·Annals of Clinical Biochemistry·Michael P CornesSeán J Costelloe

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