Spanish Society for Pediatric Infectious Diseases guidelines on tuberculosis in pregnant women and neonates (ii): Prophylaxis and treatment

Anales de pediatría : publicación oficial de la Asociación Española de Pediatría (A.E.P.)
F Baquero-ArtigaoGrupo de trabajo de tuberculosis gestacional, congénita y posnatal de la Sociedad Española de Infectología Pediátrica (SEIP)

Abstract

In pregnant women who have been exposed to tuberculosis (TB), primary isoniazid prophylaxis is only recommended in cases of immunosuppression, chronic medical conditions or obstetric risk factors, and close and sustained contact with a patient with infectious TB. Isoniazid prophylaxis for latent tuberculosis infection (LTBI) is recommended in women who have close contact with an infectious TB patient or have risk factors for progression to active disease. Otherwise, it should be delayed until at least three weeks after delivery. Treatment of TB disease during pregnancy is the same as for the general adult population. Infants born to mothers with disseminated or extrapulmonary TB in pregnancy, with active TB at delivery, or with postnatal exposure to TB, should undergo a complete diagnostic evaluation. Primary isoniazid prophylaxis for at least 12 weeks is recommended for those with negative diagnostic tests and no evidence of disease. Repeated negative diagnostic tests are mandatory before interrupting prophylaxis. Isoniazid for 9 months is recommended in LTBI. Treatment of neonatal TB disease is similar to that of older children, but should be maintained for at least 9 months. Respiratory isolation is recommended in congenital...Continue Reading

References

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Mar 3, 2009·BJOG : an International Journal of Obstetrics and Gynaecology·M KnightUNKNOWN UKOSS
May 7, 2010·Archivos de bronconeumología·Julià González-MartínJuan Ruiz-Manzano
Mar 23, 2011·Lancet·Stephen D Lawn, Alimuddin I Zumla
Dec 2, 2011·Journal of Pregnancy·Olabisi M Loto, Ibraheem Awowole
Feb 4, 2014·Enfermedades infecciosas y microbiología clínica·Rosa Polo RodríguezMaría Isabel González Tomé

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Citations

Jul 15, 2015·Anales de pediatría : publicación oficial de la Asociación Española de Pediatría (A.E.P.)·B Guarch IbáñezJ A Rodrigo Pendás
Jul 1, 2015·Enfermedades infecciosas y microbiología clínica·Teresa Del Rosal RabesMaría José Mellado Peña
Dec 1, 2017·The Pediatric Infectious Disease Journal·Laura Ferreras-AntolínFrancisco Javier Pérez-Frías

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