Sparc (Osteonectin) functions in morphogenesis of the pharyngeal skeleton and inner ear.

Matrix Biology : Journal of the International Society for Matrix Biology
Josep RotllantShao-Jun Du

Abstract

Sparc (Osteonectin), a matricellular glycoprotein expressed by many differentiated cells, is a major non-collagenous constituent of vertebrate bones. Recent studies indicate that Sparc expression appears early in development, although its function and regulation during embryogenesis are largely unknown. We cloned zebrafish sparc and investigated its role during development, using a mo rpholino antisense oligonucleotide-based knockdown approach. Consistent with its strong expression in the otic vesicle and developing pharyngeal cartilages, knockdown of Sparc function resulted in specific inner ear and cartilage defects that are highlighted by changes in gene expression, morphology and behavior. We rescued the knockdown phenotypes by co-injecting sparc mRNA, providing evidence that the knockdown phenotype is due specifically to impairment of Sparc function. A comparison of the phenotypes of Sparc knockdown and known zebrafish mutants with similar defects places Sparc downstream of sox9 in the genetic network that regulates development of the pharyngeal skeleton and inner ear of vertebrates.

References

Jun 1, 1989·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·H SageM L Iruela-Arispe
Jul 1, 1995·Developmental Dynamics : an Official Publication of the American Association of Anatomists·C B KimmelT F Schilling
Jul 1, 1995·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Y L YanJ H Postlethwait
Jan 29, 1996·The Journal of Comparative Neurology·C Haddon, J Lewis
May 1, 1997·Kidney International·K Motamed, E H Sage
Nov 11, 1998·Developmental Biology·C B KimmelH C Snyder
Nov 24, 1999·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Q Yan, E H Sage
Feb 27, 2001·Matrix Biology : Journal of the International Society for Matrix Biology·R A Brekken, E H Sage
May 9, 2001·The Journal of Clinical Investigation·A D Bradshaw, E H Sage
Aug 23, 2001·Proceedings of the National Academy of Sciences of the United States of America·R KollmarA J Hudspeth
Dec 19, 2001·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Amy D BradshawE Helene Sage
Feb 18, 2003·The Journal of Clinical Investigation·Rolf A BrekkenE Helene Sage
May 2, 2003·Proceedings of the National Academy of Sciences of the United States of America·A D BradshawE H Sage
May 15, 2003·Endocrinology·Anne M DelanyErnesto Canalis
May 16, 2003·Nature·Henry M Kronenberg
Jul 24, 2004·Proceedings of the National Academy of Sciences of the United States of America·Kazuhiko KawasakiKenneth M Weiss
Aug 21, 2004·Development·Kate F Barald, Matthew W Kelley
Sep 18, 2004·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Bhaja K PadhiMarie-Andrée Akimenko
Dec 14, 2004·Bioinformatics·D P WallA E Hirsh
Dec 18, 2004·Methods in Cell Biology·Bernard ThisseChristine Thisse
Mar 15, 2005·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Begoña RedruelloDeborah M Power
May 3, 2005·General and Comparative Endocrinology·M D EstêvãoD M Power
Aug 11, 2005·PLoS Biology·Craig E EckfeldtCatherine M Verfaillie
Dec 24, 2005·Science·Geoffrey G WhiteheadMark T Keating
Jul 28, 2006·PLoS Biology·Ching-Ling LienMark T Keating
Oct 20, 2006·Current Opinion in Cell Biology·Yasuhiko KawakamiJuan Carlos Izpisúa Belmonte
Jan 24, 2007·BMC Developmental Biology·Stefan HansMonte Westerfield

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Citations

Jan 15, 2011·Cell and Tissue Research·M Dulce EstêvãoDeborah M Power
Sep 12, 2008·Journal of the Association for Research in Otolaryngology : JARO·Young-Jin KangRichard Kollmar
Mar 1, 2013·Proceedings. Biological Sciences·Stephanie BertrandSylvain Marcellini
Mar 13, 2014·PloS One·Maurijn Y KesselsSacco C de Vries
Oct 3, 2009·Journal of Cell Communication and Signaling·Amy D Bradshaw
Dec 4, 2014·Pigment Cell & Melanoma Research·Rosa M CeinosJosep Rotllant
May 23, 2015·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Jochen WeigeleReinhard Hilbig
Mar 3, 2015·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Eva Torres-NúñezJosep Rotllant
Dec 5, 2009·Seminars in Cell & Developmental Biology·Alexandre Chlenski, Susan L Cohn
May 26, 2017·Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution·Laura CalJosep Rotllant
Nov 24, 2017·Proceedings. Biological Sciences·Katharine E CriswellJ Andrew Gillis
Sep 12, 2017·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Paula Suarez-BreguaJosep Rotllant
Oct 19, 2017·PloS One·Paula Suarez-BreguaJosep Rotllant
Dec 31, 2019·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Tanya T Whitfield
Sep 12, 2019·Scientific Reports·Sheila Castro-SánchezDiana Valverde
Feb 6, 2017·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Paula Suarez-BreguaJosep Rotllant
Aug 23, 2020·Cells·Maria Teresa ValentiLuca Dalle Carbonare
Oct 7, 2015·Frontiers in Genetics·Patsy Gómez-Picos, B Frank Eames
Aug 3, 2021·Trends in Genetics : TIG·Emily A BeckJohn H Postlethwait
Sep 8, 2021·Frontiers in Genetics·Manuel Marí-BeffaIvan Duran

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