PMID: 9632002Jun 19, 1998Paper

Sparfloxacin-induced photosensitivity and the occurrence of a lichenoid tissue reaction after prolonged exposure

Journal of the American Academy of Dermatology
H HamanakaM Shimizu

Abstract

A new antibacterial quinolone, sparfloxacin (SPFX), frequently causes photosensitive dermatitis and sometimes induces a treatment-resistant lichenoid tissue reaction (LTR). We attempted to determine the factors that induce LTR in SPFX-induced photodermatitis. Thirteen patients with SPFX photosensitive dermatitis were studied clinically and histopathologically. Six of the 13 patients had acute dermatitis with epidermal spongiosis and focal epidermal HLA-DR and intercellular adhesion molecule-1 (ICAM-1) expression with CD4+ cell infiltration. The other seven displayed LTR with basal cell liquefaction degeneration and diffuse epidermal HLA-DR and ICAM-1 expression associated with CD8+ cells. The seven patients with LTR were exposed to UV and SPFX for more than 2 weeks after the appearance of their initial eruption, whereas the six patients with acute dermatitis were treated within 2 weeks. The acute dermatitis lesions cleared significantly within 2 weeks, but the LTR lesions persisted for more than 6 weeks. Patients with quinolone-induced photosensitivity should be treated within 2 weeks of onset to prevent LTR.

References

Jan 1, 1992·The Journal of Dermatology·T ToneS Nishiyama
Jan 1, 1990·Dermatologica·B PrzybillaJ Ring
Jul 1, 1990·The British Journal of Dermatology·J Ferguson, B E Johnson
Jan 1, 1987·Dermatologica·R WolfA Krakowski
Jan 1, 1986·Clinical and Experimental Dermatology·R H Meyrick Thomas, D D Munro
Aug 1, 1973·Proceedings of the Royal Society of Medicine·C A Ramsay
May 1, 1969·The British Journal of Dermatology·D A BirkettC J Stevenson
Feb 1, 1983·Journal of the American Academy of Dermatology·J H Epstein
Apr 1, 1994·Journal of Dermatological Science·T HorioM Harada
Aug 1, 1993·Journal of the American Academy of Dermatology·S Halevy, A Shai

❮ Previous
Next ❯

Citations

Mar 12, 2011·Indian Journal of Dermatology, Venereology and Leprology·Nidhi JindalGhanshyam Kumar Verma
Feb 13, 2014·Toxicological Sciences : an Official Journal of the Society of Toxicology·Jens SchümannDaniel Bauer
Mar 6, 2009·International Journal of Dermatology·Michelle H CollazoLuz D Figueroa
Apr 22, 2005·The Australasian Journal of Dermatology·Vikram K Mahajan, Nand Lal Sharma
Sep 2, 2011·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Aaron M Drucker, Cheryl F Rosen
Mar 20, 2019·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Kim M BlakelyCheryl F Rosen
Mar 26, 2003·The British Journal of Dermatology·S Dogra, A J Kanwar

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.