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Sparse linear modeling of next-generation mRNA sequencing (RNA-Seq) data for isoform discovery and abundance estimation

Proceedings of the National Academy of Sciences of the United States of America

Dec 13, 2011

Jingyi Jessica LiPeter J Bickel

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Abstract

Since the inception of next-generation mRNA sequencing (RNA-Seq) technology, various attempts have been made to utilize RNA-Seq data in assembling full-length mRNA isoforms de novo and estimating abundance of isoforms. However, for genes with more than a few exons, the problem tends to ...read more

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    • References24
    • Citations33
  • Sparse linear modeling of next-generation mRNA sequencing (RNA-Seq) data for isoform discovery and abundance estimation

    Proceedings of the National Academy of Sciences of the United States of America

    Dec 13, 2011

    Jingyi Jessica LiPeter J Bickel

    PMID: 22135461

    DOI: 10.1073/pnas.1113972108

    Abstract

    Since the inception of next-generation mRNA sequencing (RNA-Seq) technology, various attempts have been made to utilize RNA-Seq data in assembling full-length mRNA isoforms de novo and estimating abundance of isoforms. However, for genes with more than a few exons, the problem tends to ...read more

    8
    234

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    • Citations33
    • References24
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