Sparsity enhanced spatial resolution and depth localization in diffuse optical tomography.

Biomedical Optics Express
Venkaiah C KavuriHanli Liu

Abstract

In diffuse optical tomography (DOT), researchers often face challenges to accurately recover the depth and size of the reconstructed objects. Recent development of the Depth Compensation Algorithm (DCA) solves the depth localization problem, but the reconstructed images commonly exhibit over-smoothed boundaries, leading to fuzzy images with low spatial resolution. While conventional DOT solves a linear inverse model by minimizing least squares errors using L2 norm regularization, L1 regularization promotes sparse solutions. The latter may be used to reduce the over-smoothing effect on reconstructed images. In this study, we combined DCA with L1 regularization, and also with L2 regularization, to examine which combined approach provided us with an improved spatial resolution and depth localization for DOT. Laboratory tissue phantoms were utilized for the measurement with a fiber-based and a camera-based DOT imaging system. The results from both systems showed that L1 regularization clearly outperformed L2 regularization in both spatial resolution and depth localization of DOT. An example of functional brain imaging taken from human in vivo measurements was further obtained to support the conclusion of the study.

References

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Citations

Aug 15, 2014·Optics Letters·Lingling ZhaoXavier Intes
Apr 4, 2014·Journal of the Optical Society of America. A, Optics, Image Science, and Vision·Calvin B Shaw, Phaneendra K Yalavarthy
Mar 5, 2013·Journal of the Optical Society of America. A, Optics, Image Science, and Vision·Junwei ShiJing Bai
Dec 30, 2015·Biomedical Optics Express·Ruoyang YaoXavier Intes
Feb 12, 2014·Applied Optics·Manuela RomanAnuradha Godavarty
Feb 24, 2015·IEEE Transactions on Bio-medical Engineering·Yu AnJie Tian
Apr 9, 2014·IEEE Transactions on Medical Imaging·Jaya PrakashPhaneendra K Yalavarthy
Jul 24, 2014·IEEE Transactions on Medical Imaging·Chen ChenJunzhou Huang
Oct 1, 2015·Computational and Mathematical Methods in Medicine·Chengcai LengYifang Hu
Oct 25, 2013·Biomedical Optics Express·Abhinav K JhaMatthew A Kupinski
Dec 4, 2013·Biomedical Optics Express·Takeaki ShimokawaMasa-Aki Sato
Sep 2, 2016·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Shuang ZhangJie Tian
Sep 11, 2014·Journal of Biomedical Optics·Christina HabermehlStefan Haufe
Nov 30, 2019·Scientific Reports·Takamasa AndoYasunori Inoue

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Methods Mentioned

BETA
infrared spectroscopy

Software Mentioned

DOT
L1
LS
PMI
PMI ( Photon Migration Imaging )

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