Sparsity of dendritic cells and cytotoxic T cells in tumor microenvironment may lead to recurrence in basal cell carcinoma.

International Journal of Dermatology
Burcu BeksaçDilek Yapar

Abstract

Antitumor immune response affects tumor growth. The effect of antitumor immune response on recurrence has been poorly studied in basal cell carcinoma (BCC). To investigate the effects of the peritumoral immune infiltrate on BCC recurrence. A total of 30 BCC patients without recurrence and 29 BCC patients with recurrence were included in this retrospective study. Non-recurrent tumor samples as well as primary and recurrent tumor samples from the recurrent group were stained immunohistochemically with anti-CD4, CD8, CD25, FOXP3, CD68, CD163, and CD1a antibodies. Immune infiltrates were semiquantitatively evaluated. BCC tumor microenvironment was rich in CD4+ cells. CD163 expression was higher than CD68. In primary tumors of the recurrent group, CD8 expression was significantly lower than CD4 expression. CD1a expression was lower in primary tumors of the recurrent group than in nonrecurrent tumors. Our results suggest the existence of an immunosuppressive microenvironment in BCC. Lower CD8+ T-cell numbers and sparsity of dendritic cells in primary tumors of recurrent patients suggest further immunosuppression in the tumor microenvironment and an increase in recurrence risk. This is the first study that evaluates and compares tumor...Continue Reading

References

Jul 1, 1977·The British Journal of Dermatology·J ViacJ Thivolet
Apr 23, 2002·The British Journal of Dermatology·Thomas L Diepgen, V Mahler
Jul 28, 2006·The American Journal of Dermatopathology·Prahbjot KaurJ Andrew Carlson
Aug 15, 2006·Immunological Reviews·Ethan M ShevachAngela M Thornton
May 18, 2007·The Journal of Investigative Dermatology·Helen G KaporisJohn A Carucci
Jul 22, 2008·Journal of the European Academy of Dermatology and Venereology : JEADV·H RotsztejnE Trznadel-Budźko
Mar 6, 2009·International Journal of Dermatology·Vincenzo De GiorgiDaniela Massi
Jun 4, 2010·Anais Brasileiros De Dermatologia·Itamar SantosReginaldo Alves dos Santos
Sep 3, 2010·Transplantation·David G LottRobert R Lorenz
Jul 7, 2011·The British Journal of Dermatology·S Rangwala, K Y Tsai
Mar 23, 2012·Nature Reviews. Cancer·Drew M Pardoll
Oct 26, 2012·Methods in Molecular Biology·Rana Mroue, Mina J Bissell
Mar 29, 2014·F1000prime Reports·Fernando O Martinez, Siamon Gordon
Apr 12, 2014·European Journal of Dermatology : EJD·Myrto TrakatelliNicole Basset-Seguin
Apr 28, 2016·Acta Dermato-venereologica·Silje H OmlandRobert Gniadecki
Apr 7, 2017·Journal of Cancer·Maonan WangCan Guo
Sep 16, 2017·Archives of Craniofacial Surgery·Nam Gyun KimKyung Suk Lee
Oct 11, 2017·International Journal of Dermatology·Emerson H PadovezeMirian N Sotto
Mar 22, 2018·Immunity·Max D Wellenstein, Karin E de Visser
Dec 12, 2018·The Journal of Immunology : Official Journal of the American Association of Immunologists·Melanie BoxbergAndreas Kolk
Jan 9, 2019·Frontiers in Immunology·Chunmei Fu, Aimin Jiang

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Basal Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.