Sparstolonin B: A Unique Anti-Inflammatory Agent

Shock
Natesh YepuriRobert N Cooney

Abstract

Toll-like receptors are transmembrane proteins which sense and transmit infectious and inflammatory responses to the cells expressing them. Therapeutic strategies for the blockade of excessive Toll-like receptor signaling are being actively pursued for several diseases. Recently, Sparstolonin B, isolated from Chinese herb, which suppresses selectively Toll-like receptors has been studied in various inflammatory models. The objective of this review is to summarize the current literature regarding the use of Sparstolonin B in various in vitro and in vivo studies and to provide an overview regarding the potential use of this agent in different inflammatory diseases. Additionally, the current knowledge regarding the role of Toll-like receptors in inflammatory disease and the usage of various Toll-like receptor antagonists will be summarized. Based on our review, we believe Sparstolonin B could serve as a potential therapeutic agent for treatment of Toll-like receptor-mediated inflammatory disorders.

References

Jun 22, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Osamu TakeuchiShizuo Akira
Feb 27, 2003·The Journal of Pharmacology and Experimental Therapeutics·Maureen MullarkeyDaniel P Rossignol
Jun 7, 2003·The Journal of Infectious Diseases·Shizuo Akira, Katuaki Hoshino
May 18, 2004·The Journal of Clinical Investigation·Guangxun MengCarsten J Kirschning
Feb 25, 2006·Cell·Shizuo AkiraOsamu Takeuchi
Jan 5, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Aranya BagchiJudith Hellman
Nov 22, 2007·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Lih-Geeng ChenChing-Chiung Wang
Nov 5, 2008·Journal of Lipid Research·Linda K Curtiss, Peter S Tobias
Feb 28, 2009·International Immunology·Taro Kawai, Shizuo Akira
Apr 11, 2009·American Journal of Physiology. Gastrointestinal and Liver Physiology·Ryan UngaroMaria T Abreu
Apr 25, 2009·Pediatric Research·Eva LevyMarietta Xanthou
Nov 6, 2009·Mucosal Immunology·E C LavelleE M Creagh
Aug 14, 2010·Mediators of Inflammation·A M Piccinini, K S Midwood
Nov 26, 2010·Antioxidants & Redox Signaling·Tuanzhu HaChuanfu Li
Apr 13, 2011·Structure·Istvan BotosDavid R Davies
Jun 10, 2011·International Immunology·Susan R Quinn, Luke A O'Neill
Nov 15, 2011·Cell·Ivan ZanoniJonathan C Kagan
Jan 4, 2013·Cold Spring Harbor Perspectives in Biology·Kian-Huat Lim, Louis M Staudt
May 11, 2013·The International Journal of Biochemistry & Cell Biology·Dereck E W ChattertonPer Torp Sangild
May 18, 2013·Nature Reviews. Immunology·Luke A J O'NeillAndrew G Bowie
Jul 11, 2013·Stroke; a Journal of Cerebral Circulation·Yan-Chun WangQing-Wu Yang
Dec 25, 2013·Immunology and Cell Biology·Minou Adib-ConquyFernando Souza-Fonseca-Guimaraes
Jan 31, 2014·Experimental Biology and Medicine·Qing LiuDaping Fan
Oct 14, 2014·Frontiers in Immunology·Takumi Kawasaki, Taro Kawai

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Citations

Nov 15, 2019·Shock·Russell B HawkinsShawn D Larson
Dec 12, 2020·Frontiers in Veterinary Science·Manuel Roland SchmidliKarin Wuertz-Kozak
May 6, 2021·Journal of Cellular and Molecular Medicine·Shaozhuang LiuYongsheng Song
Jun 18, 2021·Life Sciences·Saurabh ChatterjeeRatanesh Seth

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