Spasticity - Pathogenesis, prevention and treatment strategies

Saudi Journal of Anaesthesia
Anju GhaiTushar Gupta

Abstract

This review of the long-term management of spasticity addresses some of the clinical dilemmas in the management of patients with chronic disability. It is important for clinicians to have clear objectives in patient treatment and the available treatment strategies. The review reiterates the role of physical treatment in the management, and thereafter the maintenance of patients with spasticity. Spasticity is a physiological consequence of an injury to the nervous system. It is a complex problem which can cause profound disability, alone or in combination with the other features of an upper motor neuron syndrome, and can give rise to significant difficulties in the process of rehabilitation. This can be associated with profound restriction to activity and participation due to pain, weakness, and contractures. Optimum management is dependent on an understanding of its underlying physiology, an awareness of its natural history, an appreciation of the impact on the patient, and a comprehensive approach to minimizing that impact. The aim of this article is to highlight the importance, basic approach, and management options available to the general practitioner in such a complex condition.

References

Nov 1, 1992·International Journal of Nursing Studies·E K Carr, F D Kenney
Oct 1, 1990·Annals of Neurology·B J SnowD B Calne
Mar 1, 1988·Acta Neurologica Scandinavica·M C HoogstratenJ M Minderhoud
Apr 1, 1986·British Journal of Plastic Surgery·A R RowsellG I Taylor
Jan 1, 1985·Rheumatology International·G B Langley, H Sheppeard
Oct 14, 1985·Brain Research·G G SantillanR J Bing
Jun 26, 1967·JAMA : the Journal of the American Medical Association·A A Khalili, H B Betts
Nov 1, 1984·Annals of Neurology·R R Myers, H C Powell
May 1, 1994·Indian Journal of Pediatrics·S L YadavS Chaturvedi
Aug 28, 1998·Mechanisms of Ageing and Development·A B YehudaA Globerson
Feb 12, 2000·International Journal of Rehabilitation Research. Internationale Zeitschrift Für Rehabilitationsforschung. Revue Internationale De Recherches De Réadaptation·K H Kong, K S Chua
Mar 16, 2000·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·W M KadukK K Gundlach
Oct 13, 2000·Archives of Physical Medicine and Rehabilitation·K S Chua, K H Kong
Mar 20, 2002·European Journal of Pain : EJP·Eric J VielJean J Eledjam
Aug 9, 2002·The New England Journal of Medicine·Allison BrashearUNKNOWN Botox Post-Stroke Spasticity Study Group
Sep 17, 2002·Journal of Pain and Symptom Management·Harald Breivik
Nov 20, 2002·Journal of Neurology, Neurosurgery, and Psychiatry·L JarrettA J Thompson
Jul 1, 1964·The British Journal of Psychiatry : the Journal of Mental Science·R MAGGS, R NEVILLE
Dec 16, 2003·Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association·Michael J FitzpatrickRussell F Warren
Sep 8, 2004·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Alessandro Dario, Giustino Tomei
Nov 22, 2005·Age and Ageing·M P Barnes
Feb 21, 2009·Neurorehabilitation and Neural Repair·D BensmailA Beresniak
Oct 21, 2009·Acta Anaesthesiologica Scandinavica·T AkkayaA Cakci

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Citations

Jan 1, 2015·Nature Reviews. Disease Primers·Charles R M BanghamGraham P Taylor
Oct 22, 2016·Neuromodulation : Journal of the International Neuromodulation Society·Baohua YueBrian Doty
Oct 30, 2018·Journal of Alzheimer's Disease : JAD·Isobel E M EvansLinda Clare
Jan 29, 2020·Neuromodulation : Journal of the International Neuromodulation Society·Mya Caryn SchiessRobert Plunkett
Dec 1, 2020·American Journal of Physical Medicine & Rehabilitation·Nalinda D AndraweeraVenugopal Kochiyil

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BETA
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