Spatial analysis reveals alterations of parvalbumin- and calbindin-positive local circuit neurons in the cerebral cortex of mutant mdx mice

Brain Research
D CarrettaDiego Minciacchi

Abstract

The aim of the present study was to investigate the spatial organization of selected populations of local circuit neurons in the cerebral cortex of the mutant mdx mouse, an acknowledged model of Duchenne Muscular Dystrophy. To this purpose, we quantified and compared the distribution of parvalbumin- and calbindin-positive neurons in the motor, somatosensory, visual, and anterior cingulate cortices of wild-type and mdx mice. The methodological approach was based on generation of two-dimensional Voronoi polygons from digital charts of the cell populations visualized immunohistochemically. Polygon areas were then analyzed and the derived coefficients of variation were statistically compared. Using this strategy, we were able to reveal, in mdx mice, changes involving both the above populations of interneurons. These changes were evident in the motor and anterior cingulate cortices but not in the somatosensory and visual cortices. In addition, the changes of coefficients of variation were area-specific in the cortex of mdx mice. The values increased in the motor cortex and decreased in the anterior cingulate cortex with respect to the corresponding values of wild-type animals. The present findings point out widespread alterations in...Continue Reading

References

May 1, 1992·Journal of Neuroscience Research·S TorelliF Gremo
Jan 1, 1991·Neuromuscular Disorders : NMD·F MuntoniG Serra
Sep 16, 1994·Brain Research. Developmental Brain Research·J A del RíoE Soriano
Jul 1, 1994·Neuromuscular Disorders : NMD·N BresolinD Gallotti
Jan 1, 1994·Journal of Neuroscience Methods·C DuyckaertsJ J Hauw
Nov 10, 1995·Neuroscience Letters·A SbriccoliD Minciacchi
Aug 7, 1997·Journal of Theoretical Biology·F Wallet, C Dussert
Sep 26, 1997·The Journal of Comparative Neurology·R W Guillery, K Herrup
May 20, 1998·Pediatric Neurology·S I Pascual PascualI Pascual-Castroviejo
Nov 14, 2000·Journal of Chemical Neuroanatomy·C Duyckaerts, G Godefroy
Feb 9, 2002·Brain : a Journal of Neurology·J L AndersonJ W Morley
Nov 2, 2002·The Journal of Comparative Neurology·Mary A Raven, Benjamin E Reese
Jan 14, 2003·The Anatomical Record. Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology·Claire-Bénédicte RivaraPatrick R Hof
Mar 11, 2003·Brain, Behavior and Evolution·Chet C SherwoodPatrick R Hof
Jan 16, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jasmin LalondeAvi Chaudhuri

❮ Previous
Next ❯

Citations

Feb 22, 2012·Human Molecular Genetics·Caroline PerronnetCyrille Vaillend
Jan 19, 2011·The Journal of Cell Biology·Shan Zhou, Lihsia Chen
May 26, 2012·Trends in Neurosciences·Adrian WaiteDerek J Blake
Mar 29, 2011·Neuromuscular Disorders : NMD·Clarissa M ComimJoão Quevedo
May 9, 2009·Neuroscience Letters·Clarissa M ComimJoão Quevedo
Oct 18, 2008·Experimental Neurology·Diego MinciacchiMarina Bentivoglio
Jan 17, 2009·The Journal of Comparative Neurology·Patrizia MuzziAlessandro Vercelli
Jul 22, 2014·Annals of Neurology·Nathalie DoorenweerdHermien E Kan
Jul 8, 2008·Brain Research·Magali Luci PintoRita de Cássia Ribeiro da Silva Lapa
Sep 30, 2005·IEEE Transactions on Image Processing : a Publication of the IEEE Signal Processing Society·Rodrigo Fernandez-GonzalezCarlos Ortiz-de-Solórzano
Aug 11, 2006·Current Opinion in Biotechnology·Rodrigo Fernández-GonzálezCarlos Ortiz-de-Solorzano
Dec 3, 2014·Brain Research Bulletin·Erez James CohenDiego Minciacchi
May 25, 2016·Genes, Brain, and Behavior·E RemmelinkM van Putten
Oct 30, 2016·Neuromuscular Disorders : NMD·Rubén MirandaCyrille Vaillend

❮ Previous
Next ❯

Related Concepts

Related Feeds

Barrel cortex

Here is the latest research on barrel cortex, a region of somatosensory and motor corticies in the brain, which are used by animals that rely on whiskers for world exploration.