Spatial and functional heterogeneity of follicular helper T cells in autoimmunity

Current Opinion in Immunology
Abhinav Seth, Joe Craft

Abstract

Follicular helper T cells provide signals that promote B cell development, proliferation, and production of affinity matured and appropriately isotype switched antibodies. In addition to their classical locations within B cell follicles and germinal centers therein, B cell helper T cells are also found in extrafollicular spaces - either in secondary lymphoid or non-lymphoid tissues. Both follicular and extrafollicular T helper cells drive autoantibody-mediated autoimmunity. Interfering with B cell help provided by T cells can ameliorate autoimmune disease in animal models and human patients. The next frontier in Tfh cell biology will be identification of Tfh cell-specific pathogenic changes in autoimmunity and exploiting them for therapeutic purposes.

Citations

Jan 10, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Feng ShaoLijing Jia
Jan 30, 2021·Current Rheumatology Reports·Ping-Min Chen, George C Tsokos
Mar 9, 2021·Einstein·Giovana Toledo AlonsoLuiz Vicente Rizzo
Mar 16, 2021·Frontiers in Immunology·Xiaoxue Ma, Shingo Nakayamada
Mar 26, 2021·Journal of Immunology Research·Yolanda P Alemán-GarcíaAdriana K Chávez-Rueda
Apr 6, 2021·Frontiers in Immunology·Kazuhiko HigashiokaHiroaki Niiro

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