Spatial and genetic clustering of Plasmodium falciparum and Plasmodium vivax infections in a low-transmission area of Ethiopia

Scientific Reports
Sofonias K TessemaFitsum G Tadesse

Abstract

The distribution of malaria infections is heterogeneous in space and time, especially in low transmission settings. Understanding this clustering may allow identification and targeting of pockets of transmission. In Adama district, Ethiopia, Plasmodium falciparum and P. vivax malaria patients and controls were examined, together with household members and immediate neighbors. Rapid diagnostic test and quantitative PCR (qPCR) were used for the detection of infections that were genetically characterized by a panel of microsatellite loci for P. falciparum (26) and P. vivax (11), respectively. Individuals living in households of clinical P. falciparum patients were more likely to have qPCR detected P. falciparum infections (22.0%, 9/41) compared to individuals in control households (8.7%, 37/426; odds ratio, 2.9; 95% confidence interval, 1.3-6.4; P = .007). Genetically related P. falciparum, but not P. vivax infections showed strong clustering within households. Genotyping revealed a marked temporal cluster of P. falciparum infections, almost exclusively comprised of clinical cases. These findings uncover previously unappreciated transmission dynamics and support a rational approach to reactive case detection strategies for P. falc...Continue Reading

References

Apr 22, 2004·Trends in Parasitology·Jetsumon SattabongkotLiwang Cui
May 17, 2006·Trends in Ecology & Evolution·Richard S OstfeldFelicia Keesing
Jan 27, 2007·Current Infectious Disease Reports·J Kevin BairdStephen L Hoffman
Apr 9, 2008·Epidemiology and Infection·G ChowellC Castillo-Chavez
Jun 5, 2008·The Journal of Infectious Diseases·Tamara D ClarkGrant Dorsey
Aug 22, 2009·The Lancet Infectious Diseases·Ivo MuellerHernando A del Portillo
Jul 14, 2010·PLoS Medicine·Philip BejonKevin Marsh
Nov 3, 2010·Lancet·Bruno MoonenGeoffrey Targett
Nov 3, 2010·Lancet·Richard G A FeachemRobert W Snow
Feb 4, 2012·PLoS Medicine·Teun BousemaRoly Gosling
Dec 13, 2012·Malaria Journal·Stella M ChenetAnanias A Escalante
Jun 15, 2013·The Journal of Infectious Diseases·Nicholas M DouglasRic N Price
Sep 21, 2013·Malaria Journal·Megan LittrellRichard W Steketee
Jul 1, 2015·PLoS Neglected Tropical Diseases·Cristian KoepfliIngrid Felger
Jun 19, 2016·Genetics·Robert Verity, Richard A Nichols
Aug 18, 2016·Expert Review of Anti-infective Therapy·Cindy S Chu, Nicholas J White
Nov 2, 2016·The American Journal of Tropical Medicine and Hygiene·Piero L OlliaroChansuda Wongsrichanalai
Nov 17, 2017·The American Journal of Tropical Medicine and Hygiene·Tamar E CarterDaniel A Janies
Dec 1, 2017·PLoS Medicine·Regina N RabinovichPedro L Alonso
Jan 6, 2018·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Fitsum G TadesseTeun Bousema

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Methods Mentioned

BETA
PCR
genotyping
Infection

Software Mentioned

STATA
GraphPad Prism
MavericK
R
GraphPad
QGIS

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