Abstract
S100 beta, a Ca2+ binding astrocytic brain protein implicated in brain development and neurophysiology, has elevated levels in progressive neurodegenerative diseases, Down's Syndrome, and Alzheimer Disease. Transgenic mice carrying multiple S100 beta gene copies exhibited abnormal exploratory behaviors and synaptic processes suggesting hippocampal dysfunction. Here we analyze learning in a hippocampal-dependent (spatial) as well as a non-hippocampal-dependent (nonspatial) version of the Morris water maze and compare CD1 control and CD1-derived S100 beta transgenic mice. We also investigate possible progressive age-dependent effects of S100 beta overexpression by comparing two age groups of the above mice: 3- and 16-month-old. We show that 3-month-old S100 beta transgenic mice have a spatial task-specific impairment confirming a hippocampal dysfunction. However, we found the 16-month-old transgenic mice statistically indistinguishable from their normal counterparts, a result that does not confirm progressive S100 beta transgene effects. We also show that age, independently of the transgene, impairs spatial learning, spares nonspatial learning and reference memory, but leads to behavioral rigidity.
Citations
Jan 16, 2008·Neuromolecular Medicine·R C TabataC A Shaw
Oct 3, 2006·NeuroRx : the Journal of the American Society for Experimental NeuroTherapeutics·Timothy Schallert
Sep 10, 2010·Cardiovascular Psychiatry and Neurology·Guglielmo SorciRosario Donato
Dec 17, 2004·BMC Neurology·Henrik JönssonSten Blomquist
Dec 6, 2011·PloS One·Véronique BraultYann Hérault
Feb 10, 2011·Clinical Chemistry and Laboratory Medicine : CCLM·Johann SteinerHans-Gert Bernstein
Mar 9, 2006·Behavior Genetics·Zohra SérégazaBernard Soumireu-Mourat
Nov 26, 2010·Journal of Neuropathology and Experimental Neurology·Ashish D PatelJ Marc Simard
Apr 10, 2010·Psychiatry Research·Johanna PalmioTapani Keränen
Dec 27, 2008·Biochimica Et Biophysica Acta·Rosario DonatoIleana Giambanco
Jan 6, 2009·Biochimica Et Biophysica Acta·Estelle LeclercClaus W Heizmann
Sep 28, 2007·Neuroscience Research·Mohammed Rachidi, Carmela Lopes
Sep 8, 2006·The Journal of ECT·Baer ArtsJim van Os
Sep 21, 2007·Clinical and Experimental Pharmacology & Physiology·Evelin VicenteCarlos A Gonçalves
Jul 24, 2008·Glia·Lynn A Bialowas-McGoeyPatricia M Whitaker-Azmitia
Jun 26, 2010·The European Journal of Neuroscience·H N NoristaniJ J Rodríguez
Oct 29, 2010·American Journal of Medical Genetics. Part C, Seminars in Medical Genetics·Pierre L Roubertoux, Michèle Carlier
Mar 5, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Matthias RothermundtVolker Arolt
Jul 31, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Kimberly BellPatricia M Whitaker-Azmitia
Mar 20, 2003·Microscopy Research and Technique·Matthias RothermundtVolker Arolt
Jan 5, 2021·Frontiers in Behavioral Neuroscience·Alexis Buatois, Robert Gerlai
Feb 1, 2021·Cell Calcium·Carola I RadulescuSamuel J Barnes
Oct 2, 2001·Neurochemistry International·T KoppalL J Van Eldik