PMID: 2110923Mar 1, 1990Paper

Spatial and temporal control elements of the Drosophila engrailed gene

Genes & Development
Judith A Kassis

Abstract

engrailed (en) is a segmentation gene expressed in a series of stripes throughout embryonic development. Here, I show that regulatory sequences for striped expression are present within the first intron of en. The 1-kb intron is able to confer striped expression early, but not late, in development. This shows that different regulatory sequences are required for en stripes at different times in development. Furthermore, stripes generated by the intron are coincident with en stripes in a wild-type background but behave differently from endogenous engrailed stripes in some segmentation mutant backgrounds. Thus, although the intron can induce apparently normal stripes, it lacks some of the regulatory sequences present within the endogenous gene. These experiments suggest that multiple regulatory programs control an expression in stripes, and each may be able to confer "normal" spatial regulation independently.

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Citations

Nov 1, 1990·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·R J White
Jan 1, 1991·Developmental Genetics·N PerrimonA Brand
Mar 1, 1991·Mechanisms of Development·B CohenS M Cohen
Feb 1, 1992·Mechanisms of Development·M WhiteleyJ A Kassis
Mar 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·J A KassisN Perrimon
Aug 4, 1999·Proceedings of the National Academy of Sciences of the United States of America·H GuD R Schoenberg
May 26, 1998·The EMBO Journal·J DongH M Krause
Sep 26, 1997·Genes & Development·N GorfinkielI Guerrero
Apr 3, 2003·Genome Research·Alexander P LifanovDmitri A Papatsenko
Aug 14, 2009·Development·Deborah KwonJudith A Kassis
Nov 5, 1999·Biochemical and Biophysical Research Communications·A Michel, H O Gutzeit
Aug 1, 1991·Current Opinion in Genetics & Development·P W Ingham
Aug 31, 2014·Developmental Biology·Yuzhong ChengJudith A Kassis
Aug 30, 2008·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Hiroshi OchiaiTakashi Yamamoto
Nov 23, 2013·Evolution & Development·Alison HefferLeslie Pick
Nov 16, 2011·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Scott Barolo
Sep 14, 2012·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Nicolás Frankel
Jul 13, 2007·Mechanisms of Development·Laura Beaster-JonesLinda Z Holland
Feb 16, 2011·Developmental Biology·Máximo Ibo GalindoJuan Pablo Couso
Jul 14, 2007·Developmental Biology·Alysia D Vrailas-MortimerDaniel R Marenda
Aug 15, 2009·Developmental Biology·Hui Ying HouLeslie Pick
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Jul 1, 1991·Molecular and Cellular Biology·B FlorenceA Laughon
Nov 1, 1993·Genes & Development·D WilsonC Desplan

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