PMID: 9543413Apr 16, 1998Paper

Spatial and temporal differentiation of fMRI BOLD response in primary visual cortex of human brain during sustained visual simulation

Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine
W ChenK Ugurbil

Abstract

The blood oxygenation level dependent (BOLD) response during sustained visual stimulation has been studied by several groups using fMRI with controversial conclusions. This issue was investigated for the human brain at high (4 Tesla) magnetic field strength using a flashing goggle at 8 Hz. The results demonstrate that the overall BOLD response in the primary visual cortex has an initial overshoot after the onset of visual stimulation and an undershoot after the termination of visual stimulation. A significant and positive BOLD response, however, remains constant between the initial and terminal transient responses. The temporal BOLD responses in the primary visual cortex were spatially dependent. The regions identified as draining veins in images displayed proportionately larger initial and terminal transient responses, whereas regions devoid of such vessels and associated mainly with parenchyma exhibited a more time-independent BOLD response. These results reveal that the BOLD effect and, presumably, the uncoupling between cerebral blood flow and cerebral metabolic rate of oxygen consumption, are maintained in the primary visual cortex during sustained visual stimulation, and the temporal characteristics of the BOLD effect are...Continue Reading

References

Sep 1, 1992·Journal of Magnetic Resonance Imaging : JMRI·J FrahmW Hänicke
Oct 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·D L RothmanR G Shulman
Nov 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·A M BlamireR G Shulman
Jun 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·K K KwongR Turner
Jul 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·S OgawaK Ugurbil
Dec 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·S OgawaD W Tank
Apr 1, 1990·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·S OgawaP Glynn
Oct 1, 1990·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·S Ogawa, T M Lee
Oct 5, 1986·Nature·P T FoxD C Van Essen
Jun 1, 1995·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·A T LeeC H Meyer
Jul 1, 1994·Journal of Magnetic Resonance Imaging : JMRI·G M HathoutR M Harper
Aug 1, 1993·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·P A BandettiniJ S Hyde
Sep 1, 1993·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·R S MenonK Uğurbil
Feb 1, 1993·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·R TurnerR S Balaban
May 1, 1993·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·T KatoT Ozaki
Feb 1, 1996·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·J FrahmA Kleinschmidt
Jun 1, 1996·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·G KrügerJ Frahm
Jun 1, 1996·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·S G KimK Uğurbil
Jul 23, 1996·Proceedings of the National Academy of Sciences of the United States of America·F HyderR G Shulman
Apr 1, 1997·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·P P MitraK Uğurbil
Jun 1, 1997·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·X HuK Uğurbil
Nov 5, 1997·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·W ChenK Ugurbil

❮ Previous
Next ❯

Citations

May 20, 1999·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·J F DunnM E Meyerand
Nov 5, 1999·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·J B MandevilleB R Rosen
Mar 10, 2001·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·W ChenK Ugurbil
Sep 11, 2001·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·C JanzJ Hennig
Nov 27, 1998·Neuroscience Research·P DassonvilleJ Ashe
Dec 20, 2003·Magnetic Resonance Imaging·Toshiharu NakaiKayako Matsuo
Jan 15, 1999·Magnetic Resonance Imaging·P FranssonJ Frahm
Aug 31, 1999·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·A M Howseman, R W Bowtell
May 24, 2008·NeuroImage·Tal YarkoniJeffrey M Zacks
Jan 17, 2012·NeuroImage·Afonso C Silva
Jul 6, 2010·NeuroImage·Stephen M LaConte
Apr 14, 2009·NeuroImage·Hiroshi HoriguchiBrian A Wandell
Oct 14, 2005·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Essa YacoubNoam Harel
Sep 25, 2003·Human Brain Mapping·Michael D NoseworthySonya Bells
Apr 22, 2003·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Jiongjiong WangJohn A Detre
Dec 25, 2004·Physiological Reviews·Jean-François DémonetDominique Cardebat
Nov 30, 2006·Human Brain Mapping·Stephen M LaConteXiaoping P Hu
Apr 16, 1999·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·E YacoubX Hu

❮ Previous
Next ❯

Related Concepts

Related Feeds

BRAIN Initiative Cell Census Network (BICCN)

The BRAIN Initiative Cell Census Network aims to identify and provide experimental access to the different brain cell types to determine their roles in health and disease. Discover the latest research from researchers in the BRAIN Initiative Cell Census Network here.

Related Papers

Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine
P FranssonJ Frahm
Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine
G KrügerJ Frahm
Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine
J FrahmA Kleinschmidt
© 2022 Meta ULC. All rights reserved