Spatial and temporal dynamics of the cardiac mitochondrial proteome

Expert Review of Proteomics
Edward LauPeipei Ping

Abstract

Mitochondrial proteins alter in their composition and quantity drastically through time and space in correspondence to changing energy demands and cellular signaling events. The integrity and permutations of this dynamism are increasingly recognized to impact the functions of the cardiac proteome in health and disease. This article provides an overview on recent advances in defining the spatial and temporal dynamics of mitochondrial proteins in the heart. Proteomics techniques to characterize dynamics on a proteome scale are reviewed and the physiological consequences of altered mitochondrial protein dynamics are discussed. Lastly, we offer our perspectives on the unmet challenges in translating mitochondrial dynamics markers into the clinic.

References

Jun 9, 1999·Proceedings of the National Academy of Sciences of the United States of America·C K SmithR T Sauer
Jul 25, 2000·Seminars in Cell & Developmental Biology·M Käser, T Langer
Aug 29, 2002·Nature Cell Biology·Daniela A Bota, Kelvin J A Davies
Jul 30, 2003·Circulation·Joseph Loscalzo
Dec 9, 2003·The Journal of Physiology·Renée Ventura-ClapierVladimir Veksler
May 18, 2005·Cardiovascular Research·Vanessa P M van EmpelLeon J De Windt
Jan 18, 2006·Molecular & Cellular Proteomics : MCP·Francesca FornerMatthias Mann
Apr 18, 2006·Cell·Leonard J FosterMatthias Mann
Jul 11, 2006·Journal of Molecular and Cellular Cardiology·Kerstin BoenglerRainer Schulz
Apr 25, 2007·The Journal of Biological Chemistry·Youfen LiYidong Bai
Jan 22, 2008·Current Biology : CB·Margaret NeuspielHeidi M McBride
Apr 5, 2008·Experimental Cell Research·Shih-Ching Lo, Mark Hannink
May 20, 2008·Journal of Proteome Research·Jun ZhangPeipei Ping
May 27, 2008·Biochimica Et Biophysica Acta·Michael LazarouMatthew McKenzie
Jul 11, 2008·Cell·David J PagliariniVamsi K Mootha
Oct 22, 2008·Expert Review of Proteomics·D Brian FosterJennifer E Van Eyk
Jan 9, 2009·BMC Systems Biology·Shai CarmiEli Eisenberg
May 15, 2009·Free Radical Biology & Medicine·Jenny K Ngo, Kelvin J A Davies
Jun 25, 2009·The International Journal of Biochemistry & Cell Biology·Jakob D WikstromOrian S Shirihai
Jul 14, 2009·Arteriosclerosis, Thrombosis, and Vascular Biology·Jinqing LiTaixing Cui
Sep 3, 2009·Molecular & Cellular Proteomics : MCP·Nadia RachdaouiStephen F Previs
Oct 27, 2009·Nucleic Acids Research·Ron MiloMichael Springer
Dec 4, 2009·The Biochemical Journal·Vian AzzuMartin D Brand
Jan 28, 2010·Journal of Cell Science·Vian Azzu, Martin D Brand
Feb 9, 2010·Stem Cell Research·Ruenn Chai LaiSai Kiang Lim
Jul 30, 2010·Cardiovascular Research·Mariana G Rosca, Charles L Hoppel
Aug 12, 2010·Proceedings of the National Academy of Sciences of the United States of America·John C PriceSina Ghaemmaghami
Sep 2, 2010·Cardiovascular Research·Marjan Gucek, Elizabeth Murphy
Sep 3, 2010·Molecular & Cellular Proteomics : MCP·Sarah FranklinThomas M Vondriska
Oct 12, 2010·Proceedings of the National Academy of Sciences of the United States of America·Yuichi MatsushimaLaurie S Kaguni
Nov 5, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Walter A BaselerJohn M Hollander
Nov 13, 2010·Molecular Cell·Jin-Mi HeoJared Rutter
Dec 15, 2010·Biochimica Et Biophysica Acta·Roberta A Gottlieb, Asa B Gustafsson
Jan 25, 2011·Cardiovascular Research·E Dale Abel, Torsten Doenst

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Citations

Jul 4, 2015·Proteomics. Clinical Applications·Adam R Wende
Mar 16, 2016·Scientific Data·Edward LauPeipei Ping
Mar 22, 2016·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Zdenek TumaMartin Matejovic
Jan 9, 2021·Biochimica Et Biophysica Acta. Bioenergetics·Karolina Szczepanowska, Aleksandra Trifunovic
May 11, 2021·The FEBS Journal·Karolina Szczepanowska, Aleksandra Trifunovic
Oct 8, 2015·Genes & Development·Gerald W DornDaniel P Kelly

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