Spatial and temporal expression of fibril-forming minor collagen genes (types V and XI) during fracture healing

Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society
M YamazakiT A Einhorn

Abstract

Skeletal development involves the coordinated participation of several types of collagen, including both major and minor fibrillar collagens. Although much is known about the major fibrillar collagens, such as types I and II, less is known about the minor fibrillar collagens, and their role in the repair and regeneration of bone has not been extensively studied. To clarify the role of minor fibrillar collagens in fracture repair, we examined the spatial and temporal expression of mRNAs for pro-alpha 2(V) collagen and pro-alpha 1(XI) collagen in healing fractures in the rat by in situ hybridization and compared their patterns of expression with those of mRNAs for pro-alpha 1(I) collagen, pro-alpha 1(II) collagen, and osteocalcin. A strong signal for pro-alpha 2(V) was detected in the periosteal osteoprogenitor cells, whereas osteocalcin mRNA was strongly expressed only in the deep layers of the hard callus. The distribution of the pro-alpha 2(V) signal was correlated with that of pro-alpha 1(I) but was mutually exclusive of that of pro-alpha 1(II). The expression of pro-alpha 1(XI) mRNA was synchronously regulated with that of pro-alpha 1(II) during chondrogenesis in the soft callus. In the hard callus, pro-alpha 1(XI) signal wa...Continue Reading

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Citations

Nov 19, 2003·Advanced Drug Delivery Reviews·K GelseT Aigner
Aug 24, 2001·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·S HankemeierA Probst
Sep 20, 2001·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·F NakajimaM Yamazaki
Jan 10, 2002·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·K UrabeY Iwamoto
May 4, 2012·Science Translational Medicine·Suzanne ZeitouniCarl A Gregory
Nov 26, 1999·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·S SakanoL J Sandell
Nov 5, 2002·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Arata NakajimaMasashi Yamazaki
Jan 19, 2016·Journal of Developmental Biology·Anthony HafezJulia Thom Oxford
Aug 19, 2014·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Bret H CloughCarl A Gregory
Jun 11, 2002·The Journal of Biological Chemistry·Michael HadjiargyrouClinton T Rubin

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