Spatial and temporal patterns of gene expression during neurogenesis in the sea urchin Lytechinus variegatus.

EvoDevo
Leslie A SlotaDavid R McClay

Abstract

The sea urchin is a basal deuterostome that is more closely related to vertebrates than many organisms traditionally used to study neurogenesis. This phylogenetic position means that the sea urchin can provide insights into the evolution of the nervous system by helping resolve which developmental processes are deuterostome innovations, which are innovations in other clades, and which are ancestral. However, the nervous system of echinoderms is one of the least understood of all major metazoan phyla. To gain insights into echinoderm neurogenesis, spatial and temporal gene expression data are essential. Then, functional data will enable the building of a detailed gene regulatory network for neurogenesis in the sea urchin that can be compared across metazoans to resolve questions about how nervous systems evolved. Here, we analyze spatiotemporal gene expression during sea urchin neurogenesis for genes that have been shown to be neurogenic in one or more species. We report the expression of 21 genes expressed in areas of neurogenesis in the sea urchin embryo from blastula stage (just before neural progenitors begin their specification sequence) through pluteus larval stage (when much of the nervous system has been patterned). Amon...Continue Reading

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Citations

Dec 31, 2019·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Luis Alberto Bezares-CalderónGáspár Jékely
Jul 16, 2019·Frontiers in Zoology·Virginia PanaraRalf Janssen
Dec 28, 2019·Developmental Biology·Leslie A SlotaDavid R McClay

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Datasets Mentioned

BETA
MH996686
MH996683
MK015664
MK029662
MK015665
Hey

Methods Mentioned

BETA
dissection
PCR
RNAseq

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