Spatial and temporal patterns of morphogenesis of hippocampal pyramidal cells: study in the early postnatal rat

Hippocampus
M López-Gallardo, C Prada

Abstract

Several studies have dealt with the morphogenesis of the rat hippocampal pyramidal cell, but little is known about how the different pyramidal cell shapes of CA fields differentiate from neuroepithelial cells, or about how the field morphological identity emerges. From our studies of pyramidal cell shapes in the CA1, CA3, and CA4 fields of hippocampi at postnatal developmental stages between P0 and P12, using fresh semidissociated slices and acutely dissociated cells, we identified the sequence of cell shape transformation by which they differentiate from simple bipolar to complex shapes characteristic of adult pyramidal cells of CA1 and CA3. Pyramidal cell morphogenesis does not occur synchronously throughout the CA hippocampus fields, but cells in the CA4 field undergo morphological differentiation at earlier stages, prenatally, than CA3 cells, and these in turn earlier than CA1 cells. Thus, during the P1-P6 stages, a gradient of shapes from less to greater differentiation was clearly observed from CA1 to CA4 in a single slice. Furthermore, a mixture of cells at different degrees of differentiation is observed in CA1 from P1 to P10, and in CA3 from P1 to P5. A gradient of shapes from more to less differentiation was observed ...Continue Reading

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Citations

Nov 28, 2002·The European Journal of Neuroscience·Laurent GrocRoustem Khazipov
Jul 8, 2014·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Pengbo YangYong Liu
Sep 8, 2004·Journal of Neuroscience Research·Ulrich GärtnerThomas Arendt
Aug 15, 2001·The Journal of Comparative Neurology·L AnezaryC Prada
Feb 5, 2008·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Georgios PapazisisDimitrios Kouvelas
Mar 24, 2006·The European Journal of Neuroscience·Elena IsaevaGregory L Holmes
Jun 13, 2013·Neuroscience·R Khalaf-Nazzal, F Francis
Sep 28, 2007·The International Journal of Neuropsychopharmacology·Georgios PapazisisDimitrios Kouvelas
Oct 21, 2003·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Yoshinobu WakisakaToru Iwaki

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