Spatial and temporally restricted expression of chemokines and chemokine receptors in the developing human kidney.

Journal of the American Society of Nephrology : JASN
Hermann-Josef GrönePeter J Nelson

Abstract

The directed migration of cells, cell-cell adhesion, and the control of proliferation are key events during metanephric development. The chemokines are a family of proteins that selectively control aspects of cell migration, activation, proliferation, and adhesion. The expression of a series of chemokines and chemokine receptors during human renal development was investigated by using immunohistochemical analyses and real-time reverse transcription-PCR assays of defined laser-microdissected metanephric structures. The results demonstrate that mononuclear cell-like cells within the nephrogenic blastema focally express interferon-inducible protein-10/CXCL10, a ligand for CXCR3. Mononuclear-like cells dispersed through the developing organ express CX(3)CR1. Expression of CXCR4, the receptor for stromal cell-derived factor-1/CXCL12, is also limited to stromal CD34-positive cells. In contrast, the expression of stromal cell-derived factor-1/CXCL12, fractalkine, and CXCR3 is first observed in the comma- or S-shaped body stage. The intensity of this expression becomes stronger in the capillary loop stage, and expression is mainly observed in the mesangial stalk and endothelial cells of the glomeruli. These proteins may play modulatory...Continue Reading

References

May 1, 1995·Journal of Leukocyte Biology·R M StrieterS L Kunkel
Jan 1, 1996·Cytokine·I von LuettichauA M Krensky
Nov 11, 1998·Nature Medicine·L FinkR M Bohle
Dec 9, 1998·FEBS Letters·W J SchwaebleM K Schäfer
Aug 27, 1999·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·C M HogaboamS L Kunkel
Sep 10, 1999·Developmental Biology·K E McGrathJ Palis
Nov 30, 1999·Journal of the American Society of Nephrology : JASN·B BanasD Schlöndorff
Dec 10, 1999·Journal of the American Society of Nephrology : JASN·P RomagnaniM Serio
Apr 7, 2000·The American Journal of Pathology·C M HogaboamS L Kunkel
Apr 14, 2000·European Journal of Pharmacology·G A ChapmanB R Stewart
May 3, 2000·Kidney International·K NaruseH Enzan
Jun 9, 2000·Annual Review of Physiology·M PohlS K Nigam
Jun 22, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·S A BoehmeP J Conlon
Jun 28, 2000·Proceedings of the National Academy of Sciences of the United States of America·O MeucciR J Miller
Dec 20, 2000·Proceedings of the National Academy of Sciences of the United States of America·M Rosu-MylesM Bhatia

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Citations

Apr 23, 2003·Journal of the American Society of Nephrology : JASN·Frank EitnerUNKNOWN ERCB-Consortium
May 27, 2005·The Journal of Biological Chemistry·Roger SandhoffHermann-Josef Gröne
Apr 17, 2003·Current Opinion in Nephrology and Hypertension·Stephan Segerer, Charles E Alpers
Mar 23, 2004·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Holger SchmidMatthias Kretzler
Jun 29, 2002·Journal of the American Society of Nephrology : JASN·Matthias KretzlerHermann-Josef Gröne
Jun 25, 2021·Frontiers in Immunology·Sarah Cormican, Matthew D Griffin
Jun 7, 2005·Early Human Development·Wenge LuDarlene A Calhoun
Aug 20, 2005·Proceedings of the National Academy of Sciences of the United States of America·Richard JennemannHermann-Josef Gröne
Apr 21, 2005·Kidney International·Florian TögelChristof Westenfelder
Jul 19, 2005·The Journal of Clinical Investigation·Liliana SchaeferHermann-Josef Gröne
Nov 15, 2006·Clinical Transplantation·U HoffmannB K Krämer
Apr 4, 2006·Developmental Biology·Kristopher SchwabS Steven Potter
Mar 16, 2006·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Gemma MartinezMelissa H Little
Jun 21, 2007·Kidney International·M J KoziolekF Strutz
May 16, 2009·Journal of the American Society of Nephrology : JASN·Yoshitsugu TakabatakeYoshitaka Isaka
Sep 25, 2009·Nature Reviews. Nephrology·Leslie A Bruggeman, Peter J Nelson
Nov 26, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Michael J KoziolekFrank Strutz
Dec 19, 2009·The American Journal of Pathology·Matthias A NeusserClemens D Cohen
Dec 25, 2010·European Journal of Immunology·Stefan PorubskyHermann-Josef Gröne
Nov 4, 2010·Seminars in Nephrology·Jeffrey B Hodgin, Clemens D Cohen
Jan 27, 2004·The American Journal of Pathology·Stephan SegererHermann-Josef Gröne
May 27, 2004·The American Journal of Pathology·Stefan PorubskyHermann-Josef Gröne
Sep 1, 2011·Kidney International Supplements·Florian E Togel, Christof Westenfelder

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