Spatial arrangement of testicular cells disrupted by transient scrotal hyperthermia and subsequent impairment of spermatogenesis.

Andrologia
Saba IlkhaniMohammad-Amin Abdollahifar

Abstract

The spermatogenesis is temperature-dependent and heat stress have destructive effects on spermatogenesis and reduces sperm quality. Sixteen adult mice were allocated to two groups: hyperthermia and control groups. Scrotal hyperthermia was induced by water bath with 43°C for 30 min. Then, the spermatozoon was isolated through the tail region of epididymis for sperm parameters analysis. The testicular tissues were taken for stereological studies, hormonal assay, TUNEL assay and molecular studies. We found a marked decrease in sperm parameters and serum testosterone level in mice induced by scrotal hyperthermia as well as stereological analysis indicated a significant reduction in testicular cells and changes in the spatial arrangement of testicular cells in the scrotal hyperthermia groups compared to the control groups. Moreover, the TUNEL assay results showed that apoptotic cells were enhanced significantly in the group of scrotal hyperthermia compared to the control groups. Furthermore, scrotal hyperthermia caused a reduction in the expression of retinoic acid 8 (STRA8), c-kit and proliferating cell nuclear antigen (PCNA) genes in the scrotal hyperthermia groups compared to the control. According to results, induction of transi...Continue Reading

References

May 17, 1988·Biochemistry·G M Edelman
Jan 1, 1986·Annual Review of Cell Biology·G M Edelman
Aug 1, 1995·International Journal of Andrology·R Mieusset, L Bujan
Aug 1, 1997·Fertility and Sterility·C WangR S Swerdloff
Nov 2, 2004·Journal of Microscopy·R A Krasnoperov, D Stoyan
Jul 23, 2005·Free Radical Research·Tatsuya IshiiJunichi Fujii
Apr 9, 2008·Reproduction : the Official Journal of the Society for the Study of Fertility·Catriona PaulPhilippa T K Saunders
Jun 24, 2008·Journal of Andrology·Terry T Turner, Jeffrey J Lysiak
Oct 2, 2009·Oxidative Medicine and Cellular Longevity·R John Aitken, Shaun D Roman
Oct 27, 2009·Advances in Experimental Medicine and Biology·Rex A Hess, Luiz Renato de Franca
Jun 29, 2010·Journal of Microscopy·M G ReedG Staats DE Yanés
Dec 3, 2014·Reproductive Biomedicine Online·Damayanthi DurairajanayagamChloe Ong
Oct 16, 2015·Pharmaceutical Biology·Vikas Kumar RoyGuruswami Gurusubramanian
Mar 10, 2016·Asian Journal of Andrology·David F Yao, Jesse N Mills
Oct 18, 2016·Clinical Genetics·L A M DemainW G Newman
Mar 1, 2006·Reproductive Medicine and Biology·Masato Fujisawa
Jun 30, 2019·International Journal of Molecular Sciences·Natalina MoscatelliAlessandra Ferramosca

❮ Previous
Next ❯

Citations

May 8, 2021·Andrologia·Amirreza KhosraviMohammad-Amin Abdollahifar
Jul 8, 2021·Reproductive Sciences·Maryam PiraniZahra Shams Mofarahe

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie
R MieussetF Pontonnier
© 2022 Meta ULC. All rights reserved