Spatial behaviour is driven by proximal cues even in mildly impaired Parkinson's disease

Neuropsychologia
B LeplowM Mehdorn

Abstract

This investigation addresses the question whether patients with mild to moderate Parkinson's disease (PD) show spatial deficits in real-life settings. Therefore, a "search through"-locomotor task incorporating basic features of both the radial arm maze and the Morris water maze paradigms was used. The participants had to find and remember five out of twenty hidden locations within a completely controlled environment. Different spatial memory errors and inter-response intervals were recorded automatically. Fourteen patients with idiopathic PD and fourteen healthy controls matched for age, sex, handedness, and education were investigated. Patients and controls were widely comparable with respect to intelligence, verbal memory, and executive functions. Results show that performance deteriorated in about half of the patients if the starting position was moved by 90 degrees and the proximal cues were deleted simultaneously. This deficit was systematically related to specific measures of attention. Moreover, patients were less able to update their locomotor strategies towards a more effective strategy. Results are discussed with respect to the patient's inability to generate rules which can be flexibly used in changing environments, ...Continue Reading

References

Jun 1, 1978·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·H E Nelson, A O'Connell
Dec 1, 1992·Brain : a Journal of Neurology·A M OwenT W Robbins
Apr 1, 1992·Brain : a Journal of Neurology·W J JagustR A Nelson-Abbott
Jul 1, 1990·Journal of Neurology, Neurosurgery, and Psychiatry·T YamadaK Hirayama
Jul 1, 1990·Journal of Neurology, Neurosurgery, and Psychiatry·E MohrT N Chase
Nov 1, 1989·Journal of Neurology, Neurosurgery, and Psychiatry·V A BradleyD J Dick
Apr 1, 1989·Brain : a Journal of Neurology·G Goldenberg
Aug 1, 1989·The International Journal of Neuroscience·Y IwasakiK Takamiya
Mar 1, 1989·Brain and Cognition·L X BlonderH I Hurtig
Apr 1, 1988·Brain : a Journal of Neurology·R G Brown, C D Marsden
Jun 1, 1988·Journal of Neurology, Neurosurgery, and Psychiatry·R G MorrisT W Robbins
Nov 1, 1987·Neurology·S StarksteinM Berthier
Nov 1, 1987·Journal of Neurology, Neurosurgery, and Psychiatry·A HovestadtJ D Meerwaldt
Oct 1, 1986·Brain : a Journal of Neurology·R G Brown, C D Marsden
Dec 1, 1986·The British Journal of Psychiatry : the Journal of Mental Science·J R OyebodeP G Britton
Nov 1, 1986·Journal of Neurology, Neurosurgery, and Psychiatry·S Della SalaH Spinnler
Mar 1, 1987·Neurology·A HovestadtJ D Meerwaldt
Jan 1, 1974·Journal of Neurology, Neurosurgery, and Psychiatry·S Horn
Dec 1, 1981·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·S BentinH W Gordon
May 1, 1994·Neuropsychologia·A Cronin-GolombJ H Growdon
Mar 1, 1994·Neuropsychologia·E L BuytenhuijsA R Cools
Jul 1, 1993·Neuropsychologia·A M OwenT W Robbins
Mar 1, 1997·Neuropsychologia·B PillonB Dubois
Apr 9, 1998·Neuropsychologia·A C LeeJ E Calvert
Jun 23, 2000·Behavioural Brain Research·N ForemanB Leplow
May 18, 2001·International Archives of Occupational and Environmental Health·B LeplowM Reuter
Apr 1, 1961·The Journal of Nervous and Mental Disease·M RIKLAN, L DILLER
Dec 1, 1962·The Journal of Nervous and Mental Disease·M RIKLANL DILLER
Dec 1, 1963·Brain : a Journal of Neurology·J SEMMESH L TEUBER

❮ Previous
Next ❯

Citations

Apr 20, 2004·Neuropsychologia·Hans J C BergerSieberen P van der Werf
Oct 20, 2005·Cyberpsychology & Behavior : the Impact of the Internet, Multimedia and Virtual Reality on Behavior and Society·Jonathan A Stirk, Nigel Foreman
Mar 5, 2005·Movement Disorders : Official Journal of the Movement Disorder Society·Rene J StolwykJohn L Bradshaw
Sep 3, 2004·The European Journal of Neuroscience·E Decamp, J S Schneider
Nov 3, 2009·Neuropsychologia·Simone GoebelBernd Leplow
Jan 24, 2004·Perceptual and Motor Skills·Lingju ZengMaximilian Mehdorn
Aug 14, 2019·Journal of Neuroscience Methods·M L MachadoS Besnard

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved