PMID: 9550151Apr 29, 1998Paper

Spatial coding of odorant features in the glomerular layer of the rat olfactory bulb

The Journal of Comparative Neurology
B A JohnsonM Leon

Abstract

In order to determine whether molecular features of odorants are represented spatially in the glomerular layer of the olfactory bulb, we used metabolic mapping of [14C] 2-deoxyglucose uptake in rats exposed to equal vapor concentrations of odorants differing systematically in chemical structure. The odorants were ethyl acetate, ethyl butyrate, isoamyl acetate, and isoamyl butyrate. Statistical analysis of anatomically standardized arrays of uptake revealed that each ester produced a characteristic spatial pattern of activity in the glomerular layer. The patterns were similar in different rats exposed to the same odorant, and their complexity increased with increasing odorant carbon number. This finding suggests that the presence of more potentially recognized molecular features is associated with a greater number of activated receptors. Individual regions of the glomerular layer responded specifically to isoamyl esters, and other regions preferred ethyl esters. Regions of similar specificity occurred in lateral and medial aspects of the bulb, the medial representation being more caudal and ventral than the lateral one. This pattern correlates with projections of olfactory sensory neurons expressing the same putative olfactory r...Continue Reading

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Citations

Oct 22, 2003·Proceedings of the National Academy of Sciences of the United States of America·Emmanuelle ChaigneauSerge Charpak
Dec 17, 2004·Proceedings of the National Academy of Sciences of the United States of America·Leslie M Kay
Sep 2, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Carolina E ReisenmanJohn G Hildebrand
Oct 31, 2006·Chemical Senses·Cynthia C WooMichael Leon
Apr 18, 2008·Journal of Neurophysiology·Carolina E ReisenmanJohn G Hildebrand
Oct 10, 2008·Journal of Neurophysiology·John W Scott, Lisa Sherrill
Mar 19, 2009·Cellular and Molecular Life Sciences : CMLS·Michael Leon, Brett A Johnson
Dec 8, 2005·Annual Review of Entomology·Elissa A HallemJohn R Carlson
Apr 24, 2007·Nature Neuroscience·Justus V VerhagenMatt Wachowiak
Mar 31, 2012·Chemical Senses·Matteo FalasconiSantiago Marco
Oct 1, 2008·Current Opinion in Neurobiology·Rafi HaddadNoam Sobel
Apr 17, 2007·Brain Research Reviews·Gordon M ShepherdCharles A Greer
Aug 17, 2005·The European Journal of Neuroscience·Mikael A CarlssonBill S Hansson
Jan 29, 2005·The Journal of Comparative Neurology·Brett A JohnsonMichael Leon
Oct 10, 2006·The Journal of Comparative Neurology·Sabrina L HoMichael Leon
Jun 1, 2006·The Journal of Comparative Neurology·Haleh FarahbodMichael Leon
Dec 18, 2010·The Journal of Comparative Neurology·Rachel B KayPeter C Brunjes
Feb 20, 2002·Brain Research·Chunbo Zhang, Diego Restrepo
May 6, 2004·Journal of Neuroscience Methods·Angelica ZepedaFrank Sengpiel
Jun 13, 2006·Seminars in Cell & Developmental Biology·Matt Wachowiak, Michael T Shipley
Apr 1, 2008·Nature Methods·Rafi HaddadNoam Sobel
Feb 6, 2014·NeuroImage·Xiaopeng ZongJong Chul Ye
Nov 5, 2005·Neuron·Christina Zelano, Noam Sobel
Jan 15, 2014·NeuroImage·Alexander John Poplawsky, Seong-Gi Kim
Dec 7, 2007·Neuron·Silke SachseLeslie B Vosshall
Aug 4, 2009·Neural Networks : the Official Journal of the International Neural Network Society·Christiane Linster, Thomas A Cleland
Dec 8, 2005·Current Biology : CB·Elane FishilevichMatthieu Louis
Jun 29, 2013·Neuroscience and Biobehavioral Reviews·Benjamin Auffarth

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